Triamcinolone
Triamcinolone Information

About Triamcinolone

Triamcinolone and its derivatives are synthetic glucocorticoids used as anti-inflammatory or immunosuppressive agents. Triamcinolone is commercially available in oral, parenteral, topical, and aerosol formulations. Triamcinolone decreases inflammation by inhibiting the release of leukocytic acid hydrolases, preventing macrophage accumulation at the site of infection, interfering with leukocyte adhesion to the capillary wall, reducing capillary membrane permeability (thereby reducing edema), reducing complement components, inhibiting histamine and kinin release, and interfering with the formation of scar tissue. Inhaled Triamcinolone is believed to reduce the immediate and late-phase allergic responses associated with chronic bronchial asthma. Triamcinolone was approved by the FDA in 1957.

Indications

Triamcinolone is primarily indicated in conditions like Asthma, Bronchospasm, Dermatosis, Eczema, Gout, Haemolytic anaemia, Lichen planus, Lupus erythematosus, Nephrotic syndrome, Osteoarthritis, Pruritus, Psoriasis, Rheumatic fever, Rheumatoid arthritis, Suppression of inflammatory and allergic disorders, Termination of pregnancy of 13-24 weeks gestation.

Contraindication

Triamcinolone is contraindicated in conditions like Diabetes mellitus,Peptic ulcer,Psychosis,Osteoporosis,Infections,Acne vulgaris,Rosacea,Superficial leisions,Myopathy,Gravitational ulceration.

Side Effects

The severe or irreversible adverse effects of Triamcinolone, which give rise to further complications include Striae, Glaucoma, Atrophy, Steroid purpura, Skin fragility, Osteoporosis, Moon face, Buffalo hump, Distribution of fat on torso.Triamcinolone produces potentially life-threatening effects which include Cushing"s syndrome, Diabetes, Hypertension, Growth suppression, Adrenal suppression. which are responsible for the discontinuation of Triamcinolone therapy.The symptomatic adverse reactions produced by Triamcinolone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Striae, Acne, Hirsutism, Menstrual irregularity, Purpura.

Warnings

Triamcinolone should be used with caution in patients with liver, kidney, heart or intestinal disease, hypothyroidism, high blood pressure, myasthenia gravis, osteoporosis (brittle bones), herpes eye infection or a history of tuberculosis (TB), seizures, ulcers or blood clots and of any drug allergy. Do not have a vaccination, other immunization or any skin test while you are using this drug unless specifically recommended. Use aspirin, arthritis medication or alcoholic beverages cautiously while taking this medication, because it may make stomach and intestine more susceptible to the irritating effects of alcohol, aspirin and certain arthritis medications, increasing the risk of ulcers. Report any injury or signs of infection (fever, sore throat, pain during urination and muscle aches) that occur during treatment and within 12 months after treatment with this drug. Dose may need to be adjusted or may need to start taking the drug again. If patient have diabetes, this drug may increase blood sugar level. Test urine for sugar (glucose) frequently and contact the doctor if sugar is present, dose of diabetes medication and diet may need to be changed. It should be used only when clearly needed during pregnancy or lactation. Avoid use in infants because, this medication can cause growth suppression in infants.

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.