Tetracycline (HCl)
Tetracycline (HCl) Information

About Tetracycline (HCl)

Tetracycline is an antibiotic. Tetracycline is semisynthetically produced from chlortetracycline, which is derived from Streptomyces aureofaciens. It has a wide spectrum of activity against many gram-negative and gram-positive bacteria. The most common uses of tetracycline and other tetracyclines are to treat Chlamydia, Mycoplasma pneumoniae, and rickettsial and gonococcal infections. Tetracycline (HCl) is available in oral and topical preparations, including ophthalmic ointment. Tetracycline received FDA approval in 1953.

Indications

Tetracycline (HCl) is primarily indicated in conditions like Acne, Acne vulgaris, Amoebiasis, Bacterial infections, Brucellosis, Conjuctivitis, Endocarditis, Granulomatous disease, Heart failure, Long-term treatment of healed gastro-oesophageal reflux disease, Lymphogranuloma venereum, Myeloablative therapy followed by bone marrow transplantation, Myeloma, lymphoma and brain tumours, Pneumonia, Rickettsiae, Sodium depletion, Supraventricular arrhythmias (particularly atrial fibrillation), Syphilis, Trachoma, and can also be given in adjunctive therapy as an alternative drug of choice in Respiratory tract infections, Urinary tract infection.

Contraindication

Tetracycline (HCl) is contraindicated in conditions like Systemic lupus erythematosus,Renal diseases,Hepatic disease.

Side Effects

The severe or irreversible adverse effects of Tetracycline (HCl), which give rise to further complications include Increase in blood urea.Tetracycline (HCl) produces potentially life-threatening effects which include Hepatotoxicity, Anaphylaxis, Hepatic dysfunction. which are responsible for the discontinuation of Tetracycline (HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Tetracycline (HCl) include Vomiting, Diarrhea.The symptomatic adverse reactions produced by Tetracycline (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Diarrhea, Skin reactions, Stomatitis, Vaginitis, Glossitis.

Warnings

Tetracycline should be use with caution (if contains tartrazine) in patients with aspirin hypersensitivity, because it may cause allergic reactions (including bronchial asthma). Take appropriate measures if secondary infection occurs. Perform periodic lab evaluation of organ system (e.g. liver or kidney) in case of long term therapy.

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.