Terbutaline
Terbutaline Information

About Terbutaline

Terbutaline is oral and parenteral bronchodilator. Terbutaline is one of several sympathomimetic agents that act by selectively stimulating ß 2-adrenergic receptors. Clinically, its main use is in the treatment of bronchospasm, although Terbutaline is also effective in delaying premature labor. Terbutaline is available in many dosage forms. It was first approved by the FDA in 1974. its final patent expired in March 1994.

Indications

Terbutaline is primarily indicated in conditions like Asthma, Bronchitis, Emphysema, Obstructive airway disease, Oedema, Oliguria due to renal failure, Premature labour, Uncomplicated premature labor, and can also be given in adjunctive therapy as an alternative drug of choice in Acute leukemia, Lymphomas.

Contraindication

Terbutaline is contraindicated in conditions like Thyrotoxicosis,Ischaemic heart disease,Haemorrhage,Taxaemia.

Side Effects

The severe or irreversible adverse effects of Terbutaline, which give rise to further complications include Ventricular tachycardia.Terbutaline produces potentially life-threatening effects which include Pulmonary edema. which are responsible for the discontinuation of Terbutaline therapy.The signs and symptoms that are produced after the acute overdosage of Terbutaline include Tachycardia, Cardiac arrhythmias, Hypokalemia, Hyperglycemia.The symptomatic adverse reactions produced by Terbutaline are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Anxiety, Palpitation, Tremors, Muscle cramps.

Warnings

Avoid intraneural or intravascular injection of terbutaline.

High Risk Groups

Drug should not be given to Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.