Tenofovir Disoproxil
Tenofovir Disoproxil Information

About Tenofovir Disoproxil

A nucleoside reverse transcriptase inhibitor (antiviral drug), which is used in the treatment of HIV infection. There is no cure for HIV infection, so the objective of the treatment is just to reduce the viral load for extended period of time. To obtain best possible results, it is given in combination with other antiretroviral drugs. Varrying degrees of cross-resistance to tenofovir may occur by preexisting Zidovudine-associated mutations (permanent changes in genetic material). Gastrointestinal complaints are the most common side effects, but usually do not require discontinuation of therapy.

Indications

Tenofovir Disoproxil is primarily indicated in conditions like HIV infection, HIV infection in combination with other antiretroviral drugs.

Contraindication

Tenofovir Disoproxil is contraindicated in conditions like Breast feeding.

Side Effects

The symptomatic adverse reactions produced by Tenofovir Disoproxil are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Diarrhea, Nausea and vomiting, Hypophosphatemia.

Warnings

Tenofovir Disoproxil should be used with caution in patients with renal impairment, test renal function and serum phosphate before treatment, then every 4 weeks (weekly if given with nephrotoxic drug e.g cidofovir), interrupt treatment if renal function deteriorates or serum phosphate decreases; pregnancy (use only if potential benefit outweighs risk).

High Risk Groups

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.