Sulphadiazine
Sulphadiazine Information

About Sulphadiazine

Sulphadiazine is antibecterial agent, belongs to sulphonamide. It has a broad spectrum of activity, effective against gram positive, gram negative bacteria and some protozoa.

Indications

Sulphadiazine is primarily indicated in conditions like Chancroid, GI infections, Malaria, Nocardiosis, Pneumonia, Prevention of rheumatic fever recurrence, Respiratory tract infections, Superficial infections, Toxoplasmosis, Urinary tract infection, and can also be given in adjunctive therapy as an alternative drug of choice in Rheumatic fever.

Contraindication

Sulphadiazine is contraindicated in conditions like Renal failure,Porphyrias,Hepatic failure,G6pd deficiency.

Side Effects

The severe or irreversible adverse effects of Sulphadiazine, which give rise to further complications include Granulocytopenia, Nephrotic syndrome, Serum sickness like illness.Sulphadiazine produces potentially life-threatening effects which include Stevens Johnson syndrome. which are responsible for the discontinuation of Sulphadiazine therapy.The signs and symptoms that are produced after the acute overdosage of Sulphadiazine include Crystalluria.The symptomatic adverse reactions produced by Sulphadiazine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Rashes.

Warnings

Sulphadiazine should be used with caution in patients with liver or kidney disease, blood disorders or of any drug allergy. This may makes patients more prone to sunburn, wear protective clothing and (PABA-free) sunscreen when outdoors. It should be used only if clearly needed during pregnancy or lactation.

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.