Streptokinase
Streptokinase Information

About Streptokinase

Streptokinase is a nonenzymatic protein produced by group C ß-hemolytic streptococci. Clinically, Streptokinase is used as a parenteral thrombolytic agent in the management of acute myocardial infarction, pulmonary embolism, deep vein thrombosis, occluded arteriovenous cannulae, and acute arterial thrombosis and embolism. Unlike urokinase, repeated administration of it can result in tolerance and/or hypersensitivity. Streptokinase is considerably less expensive than other thrombolytics.

Indications

Streptokinase is primarily indicated in conditions like Acute myocardial infarction, Arterial thrombosis, Deep vein thrombosis, Desloughing wounds, Duodenal ulcer and gastric ulcer, Myocardial infarction, Prophylaxis of NSAID-associated gastric or duodenal ulcer, Pulmonary embolism, Thrombosis.

Contraindication

Streptokinase is contraindicated in conditions like Hypertension,Peptic ulcer,Cardiac stroke,Trauma,Bleeding diathesis.

Side Effects

Streptokinase produces potentially life-threatening effects which include Bleeding, Allergic reactions. which are responsible for the discontinuation of Streptokinase therapy.The signs and symptoms that are produced after the acute overdosage of Streptokinase include Hemorrhage.The symptomatic adverse reactions produced by Streptokinase are more or less tolerable and if they become severe, they can be treated symptomatically, these include Fever, Chills, Nausea and vomiting, Rigors.

Warnings

Before starting therapy with streptokinase determine hematocrits, platelets counts, thrombin time, prothrombin time, activated partial thromboplastin time, fibrinogen levels.

High Risk Groups

Drug should not be given to Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.