Sorbitol
Sorbitol Information

About Sorbitol

Sorbitol is a six carbon sugar alcohol formed by reduction of the carbonyl group of glucose and occuring naturally in a variety of fruits. Sorbitol is a precursor of fructose in seminal plasma.

Indications

Sorbitol is primarily indicated in conditions like Transurethral surgery, Urinary bladder irrigation, and can also be given in adjunctive therapy as an alternative drug of choice in Constipation.

Contraindication

Sorbitol is contraindicated in conditions like Renal failure,Hepatic failure,Inborn errors of metabolism.

Side Effects

The severe or irreversible adverse effects of Sorbitol, which give rise to further complications include Sinus tachycardia, Seizures, Urinary retention, Metabolic acidosis, Pulmonary congestion.Sorbitol produces potentially life-threatening effects which include Increased blood lactate. which are responsible for the discontinuation of Sorbitol therapy.The signs and symptoms that are produced after the acute overdosage of Sorbitol include Diuresis, Hyperosmolarity.The symptomatic adverse reactions produced by Sorbitol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Thirst, Nausea, Vomiting, Abdominal pain, Blurred vision, Facial flushing, SweatingX, Xerostomia.

Warnings

Sorbitol should be used with caution in patients with known subclinical diabetes mellitus. It should be given with extreme caution to patients with impaired kidney function or severe liver damage, cardiopulmonary disease, hyponatremia and in uremia.

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.