Sodium Clodronate
Sodium Clodronate Information

About Sodium Clodronate

Sodium Clodronate is a bisphosphonate. It inhibits bone resorption without affecting absorption. Sodium Clodronate is also used as an adjunct in the treatment of severe hypercalcemia. Common adverse effects include gastrointestinal disturbances.

Indications

Sodium Clodronate is primarily indicated in conditions like Hypercalcaemia, Hypercalcaemia associated with malignancy, Hypercalcaemia of malignancy, Osteolytic bone metastases, Osteolytic lesions.

Contraindication

Sodium Clodronate is contraindicated in conditions like Renal insufficiency.

Side Effects

Sodium Clodronate produces potentially life-threatening effects which include Acute Renal Failure. which are responsible for the discontinuation of Sodium Clodronate therapy.The signs and symptoms that are produced after the acute overdosage of Sodium Clodronate include Acute renal failure.The symptomatic adverse reactions produced by Sodium Clodronate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Flushing, Hypocalcemia.

Warnings

Adequate fluid intake must be maintained during sodium clodronate treatment. This is particularly important when administering sodium clodronate as intravenous infusion and in patients with hypercalcemia or renal failure. Intravenous administration of doses notably higher than those recommended may cause severe renal damage especially if the infusion rate is too high.

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.