Pyrimethamine
Pyrimethamine Information
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Pyrimethamine
medicine,pricing, side effects of Pyrimethamine medicine by company and complete information of medicines in pakistan here on this page including all packings, MG, dosage information. This list includes medicines and drugs over every region of Pakistan like Karachi, Lahore, Islamabad, Faisalabad, Rawalpindi, Multan, Peshawar, Quetta and other cities of Pakistan.About Pyrimethamine
Pyrimethamine is oral antimalarial agent. Pyrimethamine is a folic acid antagonist and dihydrofolate reductase inhibitor. Pyrimethamine is 2,4-diaminopyrimidine related to trimethoprim.
Indications
Pyrimethamine is primarily indicated in conditions like Malaria, Malaria prophylaxis, Malaria treatment, Protozoa infection, Toxoplasmosis.
Contraindication
Pyrimethamine is contraindicated in conditions like Anaemia.
Side Effects
The severe or irreversible adverse effects of Pyrimethamine, which give rise to further complications include Megaloblastic anemia.Pyrimethamine produces potentially life-threatening effects which include Agranulocytosis, Disseminated intravascular coagulation. which are responsible for the discontinuation of Pyrimethamine therapy.The signs and symptoms that are produced after the acute overdosage of Pyrimethamine include Tachycardia, Coma, Fever, Blindness, Deafness, Dyspnea.The symptomatic adverse reactions produced by Pyrimethamine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Rashes, Photosensitivity reactions.
Warnings
Pyrimethamine should be used only if clearly needed during pregnancy or lactation. It should be used with caution in patients with any pre-existing kidney disease, liver disease, blood disorders or any allergy.
High Risk Groups
Drug should not be given to Paediatrics, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Dosage
Pyrimethamine Dosage for Adults
| Dose | 25 mg |
| Single Dose | 25 (25) |
| Frequency | As recommended. |
| Route | PO |
| Note: Once in a Week |
Pyrimethamine Dosage for Paedriatic
| Dose | 0.5 mg/kg |
| Single Dose | 0.5 (0.5) |
| Frequency | 24 hourly |
| Route | Oral |
| Note: Double dose for 1st 3 days |
Brands
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