Pyrazinamide
Pyrazinamide Information
Find all the information of Pyrazinamide medicine and drugs available in Pakistan. Read the pricing, side effects, usage, instructions and dosage of Pyrazinamide by .
Pyrazinamide
medicine,pricing, side effects of Pyrazinamide medicine by company and complete information of medicines in pakistan here on this page including all packings, MG, dosage information. This list includes medicines and drugs over every region of Pakistan like Karachi, Lahore, Islamabad, Faisalabad, Rawalpindi, Multan, Peshawar, Quetta and other cities of Pakistan.About Pyrazinamide
Pyrazinamide is antituberculosis agent. Pyrazinamide is the pyrazine analogue of nicotinamide. Pyrazinamide is stable and quite inexpensive. It may be bacteriostatic or bacteriocidal against Mycobacterium tuberculosis depending on the concentration of drug attained at the site of infection. Resistance to drug emerges rapidly when the drug is used alone. Therefore Pyrazinamide is always given in combination with other antituberculosis drug.
Indications
Pyrazinamide is primarily indicated in conditions like Acute leukemia, Tuberculosis (with other anti-tuberculosis drugs), and can also be given in adjunctive therapy as an alternative drug of choice in Tuberculosis.
Contraindication
Pyrazinamide is contraindicated in conditions like Renal diseases,Hepatic disease.
Side Effects
The severe or irreversible adverse effects of Pyrazinamide, which give rise to further complications include Sideroblastic anemia, Precipitation of gout.Pyrazinamide produces potentially life-threatening effects which include Hepatitis, Hyperbilirubinemia. which are responsible for the discontinuation of Pyrazinamide therapy.The symptomatic adverse reactions produced by Pyrazinamide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Anorexia, Fever, Malaise, Arthralgia, Nausea and vomiting.
Warnings
Pyrazinamide should be used only if clearly needed during pregnancy or lactation. It should be used with caution in patients with any pre-existing kidney disease, liver disease, gout, diabetes or if have any allergy.
High Risk Groups
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Dosage
Pyrazinamide Dosage for Adults
| Dose | 20 to 35 mg/ kg |
| Single Dose | 28 (27.5) |
| Frequency | As recommended. |
| Route | PO |
| Note: Daily in 3-4 div.doses. Maximum dose: 3 g/24hr. Usually given during 1st 2 months of therapy. |
Pyrazinamide Dosage for Neonatal
| Dose | 5 mg/kg |
| Single Dose | 5 (5) |
| Frequency | 6 hourly |
| Route | Oral |
Pyrazinamide Dosage for Paedriatic
| Dose | 5 mg/kg |
| Single Dose | 5 (5) |
| Frequency | 6 hourly |
| Route | Oral |
| Note: For Paeds of All Ages |
Brands
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