Pseudoephedrine (HCl)
Pseudoephedrine (HCl) Information

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Pseudoephedrine (HCl)

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About Pseudoephedrine (HCl)

Pseudoephedrine (HCl) is a sympathomimetic agent, closely related to ephedrine. Pseudoephedrine (HCl) is used in various cough and cold preparations as a nasal decongestant, provides relief from the nasal or sinus congestion.

Indications

Pseudoephedrine (HCl) is primarily indicated in conditions like Bronchospasm, Nasal congestion, Rhinitis, Upper respiratory tract infections.

Contraindication

Pseudoephedrine (HCl) is contraindicated in conditions like Diabetes mellitus,Hypertension,Hyperthyroidism,Prostatic hypertrophy,Cardiovascular disease,Endocrine disorder.

Side Effects

Pseudoephedrine (HCl) produces potentially life-threatening effects which include Hypertension, Unconsciousness. which are responsible for the discontinuation of Pseudoephedrine (HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Pseudoephedrine (HCl) include Tachycardia, Hallucinations, Restlessness, Excitation, Hyperreflexia, Rapid Speech, Hypertonicity, Pupillary dilatation.The symptomatic adverse reactions produced by Pseudoephedrine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Anorexia, Anxiety, Restlessness, Insomnia, Sleep disturbancesX, Dry mouth, Tremor.

Warnings

Although pseudoephedrine has no significant pressure effect in normotensive patients, It should be used with caution in the patient with hypertension, patients using tricyclic antidepressants, decongestant, appetite suppressants and amphetamine like psychostimulants. Particular care should also be taken in treating patient with underlyning diseases associated with autonomic dysfunction, such as long standing insulin-dependent diabetes mellitus or thyroid disease. Other conditions also exacerbated by pseudoephedrine include myocardial ischmia, cardiac arrhythmia, glucoma, and urinary retension. Do not take the drug more than seven days. Use with great caution in the presence of liver or the kidney impairment. Use topical decongestant (pseudoephedrine) only in acute conditions, not longer than 3 to 5 days. It should be used sparingly in all patients, especially in infants, children and in cardiac patients. Patient should not derive or operate machinery until they have determined their own response. Concomitant use of alcohol or other centrally acting sedative should be avoided. not to be used in nursing mother. Not to be used in patient MAOI inhibitors.

High Risk Groups

Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Dosage

Pseudoephedrine (HCl) Dosage for Adults

Dose 60 to 240 mg
Single Dose 150 (150)
Frequency 4 hourly
Route PO
Dose 120 mg
Single Dose 120 (120)
Frequency 2 hourly
Route PO

Pseudoephedrine (HCl) Dosage for Neonatal

Dose 0.625 to 1.875 mg/kg
Single Dose 1.2 (1.25)
Frequency 8 hourly
Route Oral

Pseudoephedrine (HCl) Dosage for Paedriatic

Dose 1.5 mg/kg
Single Dose 1.5 (1.5)
Frequency 8 hourly
Route Oral
Note: -

Brands


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