Propylthiouracil
Propylthiouracil Information

About Propylthiouracil

Propylthiouracil used in treatment of hyperthyroidism (overactive thyroid gland). Propylthiouracil decreases the formation of thyroid hormone from thyroid gland.

Indications

Propylthiouracil is primarily indicated in conditions like Hyperthyroidism, Thyrotoxicosis.

Contraindication

Propylthiouracil is contraindicated in conditions like Hepatitis,Agranulocytosis,Vasculitis.

Side Effects

Propylthiouracil produces potentially life-threatening effects which include Agranulocytosis, Thrombocytopenia, Aplastic Anemia, Hepatitis, Leucopenia, LE-like syndrome, Vasculitis. which are responsible for the discontinuation of Propylthiouracil therapy.The signs and symptoms that are produced after the acute overdosage of Propylthiouracil include Vomiting, Fever, Epigastric pain, Arthralgia, Pruritus, Pancytopenia.The symptomatic adverse reactions produced by Propylthiouracil are more or less tolerable and if they become severe, they can be treated symptomatically, these include Maculopapular rash, Urticaria.

Warnings

Excessive dose of antithyroid should not be used, because it may cause hypothyroidism or goiter. Treatment should be discontinued immediately if there is any clinical or lab evidence of neutropenia. It is not recommended to use high dose during pregnancy or lactation. Before having an emergency treatment or surgery including dental surgery, tell the doctor about the use of the drug. Propylthiouracil should be use with caution in patients with blood disease.

High Risk Groups

Drug should not be given to patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.