Polymyxin B (Sulphate)
Polymyxin B (Sulphate) Information
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Polymyxin B (Sulphate)
medicine,pricing, side effects of Polymyxin B (Sulphate) medicine by company and complete information of medicines in pakistan here on this page including all packings, MG, dosage information. This list includes medicines and drugs over every region of Pakistan like Karachi, Lahore, Islamabad, Faisalabad, Rawalpindi, Multan, Peshawar, Quetta and other cities of Pakistan.About Polymyxin B (Sulphate)
Polymyxin B (Sulphate) is antibiotic derived from a strain of Bacillus polymyxa. Polymyxin B (Sulphate) is a sulfate salt of the least toxic member of the polymixin group. Polymyxin B (Sulphate) is bacteriocidal for many gram negative bacteria. Polymyxin B (Sulphate) is a cationic, basic peptide contains fatty acid D-6-methyloctan-1-oic acid and amino acids L-threonine and L-diaminobutyric acid. Polymyxin B (Sulphate) is used in the treatment of various systemic, urinary tract, otic, ophthalmic and cutaneous infections due to susceptible gram -ve bacteria. Polymyxin B (Sulphate) is administered orally, parentrally and topically, but nowadays, rarely used parentrally due to its potential for causing nephrotoxicity and/or neurotoxicity. Polymyxin B (Sulphate) is more commonly administered as either a topical or otic agent in combination with neomycin or bacitracin. Polymyxin B (Sulphate) is also available in ophthalmic solutions in combination with either trimethoprim B or in combination with bacitracin and neomycin. Polymyxin B is also used in combination with neomycin as a urinary tract irrigant. Polymyxin B was originally approved by the FDA in 1951.
Indications
Polymyxin B (Sulphate) is primarily indicated in conditions like Bacteremia, Meningitis, Superficial infections, Urinary tract infection, and can also be given in adjunctive therapy as an alternative drug of choice in Joint infections, Skin infections.
Contraindication
Polymyxin B (Sulphate) is contraindicated in conditions like Hypersensitivity to the drug.
Side Effects
The severe or irreversible adverse effects of Polymyxin B (Sulphate), which give rise to further complications include Convulsions, Coma, Psychosis, Hypersensitivity reactions, Neuromuscular blockage.Polymyxin B (Sulphate) produces potentially life-threatening effects which include Nephrotoxicity, Neurotoxicity, Hematuria, Respiratory paralysis. which are responsible for the discontinuation of Polymyxin B (Sulphate) therapy.The symptomatic adverse reactions produced by Polymyxin B (Sulphate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Drowsiness, Ataxia, Nausea, Vomiting, Blurred vision, Confusion, Urticaria, Flushing, Muscle weakness, Paresthesias, Proteinuria, Reaction at injection site, Azotemia.
Warnings
Before initiating therapy with polymyxin B determine baseline kidney function. Serum concentration must be monitored regularly during treatment. It should be used with caution in patients with renal impairment, mysthania gravis or other condition of neuromuscular disease, in patients known to have hypersensitivity reactions, in pulmonary disease, if sign of respiratory distress or nephrotoxicity occur, the drug should be discontinued. Take appropriate measures in case of secondary infection.
High Risk Groups
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Dosage
Polymyxin B (Sulphate) Dosage for Adults
| Dose | 15000 to 30000 units/kg/day |
| Single Dose | 22000 (22500) |
| Frequency | 24 hourly |
| Route | IM |
| Note: This should be reduced in the presence of renal impairment.The dosage may be divided and given at either 4 or 6 hour intervals. | |
| Dose | 15000 to 25000 units/kg/body weight/day |
| Single Dose | 20000 (20000) |
| Frequency | 24 hourly |
| Route | IV |
| Note: Infusions may be given every 12 hours, however, the total daily dose must not exceed 25,000 units/kg/day. | |
| Dose | 5 to 10 ml |
| Single Dose | 7.5 (7.5) |
| Frequency | 6 hourly |
| Route | Ophthalmic |
| Note: Frequency may be increased upto 6 times/day. | |
| Dose | 10000 units/g |
| Single Dose | 10000 (10000) |
| Frequency | 12 hourly |
| Route | Ophthalmic,Otic |
| Note: Ointment | |
| Dose | 1 stripe |
| Single Dose | 1 (1) |
| Frequency | 12 hourly |
| Route | Topical |
| Note: Apply Ointment on effacted area. |
Polymyxin B (Sulphate) Dosage for Neonatal
| Dose | 0.25 mg/kg |
| Single Dose | 0.25 (0.25) |
| Frequency | 24 hourly |
| Route | Intrathecal |
Polymyxin B (Sulphate) Dosage for Paedriatic
| Dose | 0.33 mg/kg |
| Single Dose | 0.33 (0.33) |
| Frequency | 24 hourly |
| Route | Intrathecal |
| Note: For above 2 yrs children |
Brands
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