Piroxicam-beta-cyclodextrin
Piroxicam-beta-cyclodextrin Information
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Piroxicam-beta-cyclodextrin
medicine,pricing, side effects of Piroxicam-beta-cyclodextrin medicine by company and complete information of medicines in pakistan here on this page including all packings, MG, dosage information. This list includes medicines and drugs over every region of Pakistan like Karachi, Lahore, Islamabad, Faisalabad, Rawalpindi, Multan, Peshawar, Quetta and other cities of Pakistan.About Piroxicam-beta-cyclodextrin
Piroxicam-beta-cyclodextrin is a complex of the nonsteroidal antiinflammatory drug (NSAID) piroxicam and an inert cyclic macromolecule, beta-cyclodextrin. In clinical trials in patients with pain or rheumatic diseases arising from other conditions, it was as effective an analgesic as standard piroxicam, and showed a faster onset of action on the first day of treatment. In healthy volunteers short term pharmacodynamic studies showed, piroxicam-beta-cyclodextrin was equivalent to or tended to show less gastrointestinal mucosal toxicity than standard piroxicam, as evaluated by endoscopy and faecal blood loss
Indications
Piroxicam-beta-cyclodextrin is primarily indicated in conditions like Acute gout, Acute musculoskeletal disorders, Acute pain, Ankylosing spondylitis, Backache, Dysmenorrhoea, Juvenile chronic arthritis, Migraine, Osteoarthritis, Post operative pain, Rheumatic diseases, and can also be given in adjunctive therapy as an alternative drug of choice in Juvenile rheumatoid arthritis.
Contraindication
Piroxicam-beta-cyclodextrin is contraindicated in conditions like Asthma,Peptic ulcer,Thrombosis,Rhinitis,Urticaria,Impaired hepatic function,Hypersensitivity,Angioedema.
Side Effects
The severe or irreversible adverse effects of Piroxicam-beta-cyclodextrin, which give rise to further complications include Skin reactions, Erythema, Interstitial nephritis.Piroxicam-beta-cyclodextrin produces potentially life-threatening effects which include GI bleeding, Aplastic Anemia, Renal damage, Peptic ulceration, Purpura, Pemphigus vulagris. which are responsible for the discontinuation of Piroxicam-beta-cyclodextrin therapy.The signs and symptoms that are produced after the acute overdosage of Piroxicam-beta-cyclodextrin include Nausea, Vomiting, Diarrhea, Convulsions, Coma, Hematuria, Acute renal failure, Dizziness, Headache, Hyperventilation, Rashes, Proteinuria, Hyperreflexia, Tinnitus, Hypoprothrombinemia, GI bleeding, hyper reflexia.The symptomatic adverse reactions produced by Piroxicam-beta-cyclodextrin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Skin irritation, Nausea and vomiting, Edema, GI disturbance, Erythema multiforme, Azotemia, bronchoconstriction.
Warnings
Piroxicam should be used with caution in patients with intrinsic coagulation defects and those on anticoagulant therapy. It should be used with caution in patients with compromised cardiac function, hypertension other condition predisposing to fluid retention. Discontinue drug if skin reaction occurs. It should be used with extra care in the presence of existing controlled infection.
High Risk Groups
Drug should not be given to Pregnant Mothers, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Dosage
Piroxicam-beta-cyclodextrin Dosage for Adults
| Dose | 10 to 20 mg |
| Single Dose | 15 (15) |
| Frequency | 1 hourly |
| Route | IM |
| Note: For orthopedic surgery administer 40 mg OD for 2 days followed by 20 mg OD | |
| Dose | 10 to 20 mg |
| Single Dose | 15 (15) |
| Frequency | 1 hourly |
| Route | PO |
| Note: For orthopedic surgery administer 40 mg OD for 2 days followed by 20 mg OD |
Brands
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