Phenylbutazone
Phenylbutazone Information

About Phenylbutazone

Phenylbutazone is a congener of aminopyrine and antipyrine, having analgesic, antipyretic, antinflammatory and mild uricosuric properties; rapidly gained favour after its introduction in 1949 for the treatment of inflammatory joint disordes. Phenylbutazone is used in the treatment of gout, ankylosing spondylitis But it has a large number of serious adverse effects.

Indications

Phenylbutazone is primarily indicated in conditions like Acute gout, Advanced prostate cancer, Agitation and restlessness in the elderly, Ankylosing spondylitis, Nausea and vomiting (palliative care), Pain, Schizophrenia and other psychoses, and can also be given in adjunctive therapy as an alternative drug of choice in Bone pain, Gout, Osteoarthritis, Psoriatic arthritis, Reiters disease, Rheumatic fever, Rheumatoid arthritis, Thrombophlebitis.

Contraindication

Phenylbutazone is contraindicated in conditions like Peptic ulcer,Blood dyscrasias,Congestive heart failure,Hepatitis.

Side Effects

The severe or irreversible adverse effects of Phenylbutazone, which give rise to further complications include Hepatitis, Exfoliative dermatitis, Peptic ulceration, Goitre, Chromosomal damage, Gastric erosions.Phenylbutazone produces potentially life-threatening effects which include Pulmonary edema, Blood dyscrasias, Bleeding, Cardiac failure, Peptic ulceration, Perforation. which are responsible for the discontinuation of Phenylbutazone therapy.The signs and symptoms that are produced after the acute overdosage of Phenylbutazone include Death, Acidosis, Acute renal failure, Encephalitis, Neurological syndrome, Acute hepatitis.The symptomatic adverse reactions produced by Phenylbutazone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Rashes, Stomatitis, Hematuria, Rectal bleeding, Salivary gland swelling, Increased intracranial pressure.

Warnings

Phenylbutazone should be used with caution in patients with incipient cardiac failure, blood dyscrasias, pancreatitis, kidney or liver diseases, gastrointestinal (GI) inflammation.patients should observe caution while driving or performing other tasks requiring alertness, because it may cause drowsiness.

High Risk Groups

Drug should not be given to Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.