Pergolide
Pergolide Information

About Pergolide

Pergolide is a synthetic ergot derivative and a dopaine agonist, directly stimulates both D1 and D2 receptors.Chemically Pergolide is 8-(methylthio)methyl]-6-propylergoline. Pergolide is used in Parkinson"s disease as an adjunct to levodopa/carbidopa, prolongs the response to Levodopa in patients with response fluctuation. The drug may also benefit patients not receiving Levodopa. It works by stimulating dopamine receptors in the brain.

Indications

Pergolide is primarily indicated in conditions like Parkinsonism, Parkinson's disease (adjunctive with levodopa), Parkinson's disease (monotherapy), and can also be given in adjunctive therapy as an alternative drug of choice in Hyperprolactinaemia, Tourette's syndrome.

Contraindication

Pergolide is contraindicated in conditions like Valvular heart disease,Pericarditis,Valvular heart disease,Fibrositis,Hypersensitivity to any component of product.

Side Effects

The severe or irreversible adverse effects of Pergolide, which give rise to further complications include Cardiac arrhythmias, Rashes, Allergic reactions, Syncope, Chest pain, Myocardial infarction.The signs and symptoms that are produced after the acute overdosage of Pergolide include Seizures, Fainting, Agitation, Nausea & vomiting, Tingling.The symptomatic adverse reactions produced by Pergolide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Dizziness, Drowsiness, Nausea, Anorexia, Diarrhea, Anxiety, Palpitation, Tremors, Constipation, Dry mouth, Confusion, Hallucination, SomnolenceX, Rhinitis, Dystonic reactions, Stomachache, Vasodilation, Loss of appetite, Stomach upset.

Warnings

Pergolide should be used with caution in patients with pre-existing heart disease or a history of heart arrhythmias (abnormal rhythms), hallucinations, mental confusion, difficulty in walking, allergies, kidney disease or low blood pressure. Caution should be exercised when administering pergolide mesylate to patients prone to cardiac dysrhythmias. In a study comparing pergolide mesylate and placebo, patients taking pergolide mesylate were found to have signifiscantly more episodes premature contractions (PACs) and sinus tachycardia. Patients and their families should be informed of the common adverse consequences of the use of pergolide mesylate and the risk of hypotension. Patients should be advised to notify their physician if they become pregnant or intend to become pregnant during therapy. Patients should be advised to notify their physician if they are breast feeding an infant. Liver disease may alter the response to drugs in several ways. Prescribing should be kept to a minimum in all patients with severe liver disease, especially if jaundice, ascites, or evidence of encephalopathy present. Consider dose reduction in renal failure to avoid possibility of toxicity, increased sensitivity, and side effects. Get up slowly, to avoid dizziness and lightheadedness when rising from a seated or lying position. It should be used with caution when performing tasks requiring mental alertness such as driving or using machinery. Limit alcohol use because it may intensify the drowsiness and dizziness effects of this drug. It should be used with caution during pregnancy.

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.