Octreotide (Acetate)
Octreotide (Acetate) Information

About Octreotide (Acetate)

Octreotide (Acetate) is a parenteral synthetic analogue of the naturally occurring hormone somatostatin. The activity of octreotide is similar to that of somatostatin. Octreotide, however, has a longer half-life, greater selectivity for inhibiting glucagon, growth hormone, and insulin release, and a lower incidence of rebound hypersecretion following discontinuation. Based on this activity, octreotide has been approved for use in controlling the symptoms associated with vasoactive intestinal peptide tumors (VIPomas; watery diarrhea) and metastatic carcinoid tumors (flushing and diarrhea). Other non-approved uses of octreotide include AIDS-associated diarrhea, esophageal varices, and pituitary tumors (i.e., acromegaly and thyrotropinomas).

Indications

Octreotide (Acetate) is primarily indicated in conditions like Acromegaly, Adjunct in ganciclovir treatment, Carcinoid tumours, Glucagonoma, Hormone-mediated secretory diarrhea, To reduce intestinal secretions and vomiting (palliative care), Variceal bleeding, Vipoma, and can also be given in adjunctive therapy as an alternative drug of choice in Acromegaly (short-term treatment before pituitary surgery), Hormone-mediated secretory diarrhea (can be benefit in refactory cases), Symptoms associated with carcinoid tumours, To reduce intestinal secretions and vomiting.

Contraindication

Octreotide (Acetate)

Side Effects

The severe or irreversible adverse effects of Octreotide (Acetate), which give rise to further complications include Gall stones.Octreotide (Acetate) produces potentially life-threatening effects which include Hypoglycemia, Hypoglycemia, Hypoglycemia, Hepatic dysfunction, Acute pancreatitis. which are responsible for the discontinuation of Octreotide (Acetate) therapy.The symptomatic adverse reactions produced by Octreotide (Acetate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Loose stools, Anorexia, Abdominal pain, Pain, Local pain, Local reactions, Nausea and vomiting, Tingling, Steatorrhea, Tenderness, Bloating, Stinging.

Warnings

Octreotide should be used with caution in patients with kidney disease, diabetes, any other illness or any allergy. Check should be made for gallstone before prolonged therapy and at 6 to 12 months interval during treatment.

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.