Norfloxacin
Norfloxacin Information
Find all the information of Norfloxacin medicine and drugs available in Pakistan. Read the pricing, side effects, usage, instructions and dosage of Norfloxacin by .
Norfloxacin
medicine,pricing, side effects of Norfloxacin medicine by company and complete information of medicines in pakistan here on this page including all packings, MG, dosage information. This list includes medicines and drugs over every region of Pakistan like Karachi, Lahore, Islamabad, Faisalabad, Rawalpindi, Multan, Peshawar, Quetta and other cities of Pakistan.About Norfloxacin
Norfloxacin is a fluoroquinolone antibacterial agent, structurally related to nalidixic acid. Due to it's relatively poor oral bioavailability, its clinical use is limited to the treatment of urinary tract infections and uncomplicated gonorrhea. Norfloxacin is also approved for use as an ophthalmic solution for bacterial conjunctivitis. It has the shortest half-life of all currently available fluoroquinolones. It was initially approved for systemic use by the FDA in October 1986. Norfloxacin is bactericidal via its effects on DNA gyrase, an enzyme responsible for counteracting the excessive supercoiling of DNA during replication or transcription. Although human cells do not contain DNA gyrase, they do contain a topoisomerase enzyme that functions in the same manner. This mammalian enzyme is not affected by bactericidal concentrations of quinolones. Norfloxacin is unclear how inhibition of DNA gyrase leads to bacterial cell death. Both rapid and slow growing organisms are inhibited by fluoroquinolones.
Indications
Norfloxacin is primarily indicated in conditions like Bacterial enteric infections, Carvicitis, Cervicitits, Chronic prostatitis, Chronic relapsing UTIS, Gonorrhoea, Urethritis, Urinary tract infection, UTI, and can also be given in adjunctive therapy as an alternative drug of choice in Eye infections.
Contraindication
Norfloxacin is contraindicated in conditions like Epilepsy,Hypersensitivity.
Side Effects
The severe or irreversible adverse effects of Norfloxacin, which give rise to further complications include Hepatitis, Hemolytic anemia, Hemolytic anemia, Seizures, Exfoliative dermatitis, Interstitial nephritis, Hemolytic anemia.The signs and symptoms that are produced after the acute overdosage of Norfloxacin include Crystalluria, Drowsiness, Acute renal failure, GI disturbances.The symptomatic adverse reactions produced by Norfloxacin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Diarrhea, Fever, Constipation, Insomnia, Dry mouth, Rashes, GI symptoms, Depression, Arthralgia, Heart burn, Crystalluria, Tendinitis, Dry mouth.
Warnings
Norfloxacin should be used only if clearly needed during pregnancy or lactation. It should be used with caution in patients with eye problems or allergies, especially to any antibiotics.
High Risk Groups
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Dosage
Norfloxacin Dosage for Adults
| Dose | 0.3 % |
| Single Dose | 0.3 (0.3) |
| Frequency | 6 hourly |
| Route | Ophthalmic |
| Dose | 400 mg |
| Single Dose | 400 (400) |
| Frequency | 12 hourly |
| Route | PO |
| Note: For 7 to 10 days |
Norfloxacin Dosage for Neonatal
| Dose | Not used in children |
| Single Dose | |
| Frequency | |
| Route |
Norfloxacin Dosage for Paedriatic
| Dose | Not indicated in peads |
| Single Dose | |
| Frequency | |
| Route |
Brands
Community Contribution
Do you know any authentic drug which is not listed here? Please let us know.