Nicorandil
Nicorandil Information

About Nicorandil

Nicorandil is a derivative of nicotinamide, acts as a vasodilator and facilitates the opening of potassium-channels. It produces vasodilation of arterioles and large coronary arteries, while the nitrate component produces venous vasodilatation. Nicorandil is used in the management of angina pectoris.

Indications

Nicorandil is primarily indicated in conditions like Acute heart failure, Stable angina pectoris, Unstable angina.

Contraindication

Nicorandil is contraindicated in conditions like Cardiogenic shock,Hypotension,Left ventricular failure,Additional vascular conditions.

Side Effects

The severe or irreversible adverse effects of Nicorandil, which give rise to further complications include Hepatic function abnormilities.The signs and symptoms that are produced after the acute overdosage of Nicorandil include Hypotension.The symptomatic adverse reactions produced by Nicorandil are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Dizziness, Headache, Fatigue, Nausea, Vomiting, Myalgia, Palpitation, Skin rash, Malaise, Hypotension, Flushing, Angioedema, dizziness, Weakness, Hypotension.

Warnings

It should be used with caution in patients with hypovolemia, low systolic blood pressure or acute pulmonary edema.

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.