Neomycin
Neomycin Information
Find all the information of Neomycin medicine and drugs available in Pakistan. Read the pricing, side effects, usage, instructions and dosage of Neomycin by .
Neomycin
medicine,pricing, side effects of Neomycin medicine by company and complete information of medicines in pakistan here on this page including all packings, MG, dosage information. This list includes medicines and drugs over every region of Pakistan like Karachi, Lahore, Islamabad, Faisalabad, Rawalpindi, Multan, Peshawar, Quetta and other cities of Pakistan.About Neomycin
Neomycin is an aminoglycoside antibiotic. The aminoglycosides are the compound containing characteristic amino sugars joined to a hexose nucleus in glycoside linkage Neomycin (Sulphate) is derived from cultures of Streptomyces fradiae. Although bioavailability after oral administration is poor, neomycin is administered orally in patients with hepatic coma or portal-systemic encephalopathy. Neomycin (Sulphate) is most often used topically as an antiinfective. Neomycin is not indicated for the treatment of systemic infections because it can cause irreversible ototoxicity. Neomycin was approved by the FDA in 1952. Neomycin is bactericidal in action. It inhibits bacterial protein synthesis through irreversible binding to the 30 S ribosomal subunit of susceptible bacteria. Neomycin is actively transported into the bacterial cell where it binds to receptors present on the 30 S ribosomal subunit. This binding interferes with the initiation complex between the messenger RNA (mRNA) and the subunit. As a result, abnormal, nonfunctional proteins are formed due to misreading of the bacterial DNA. Eventually, susceptible bacteria die because of the lack of functional protein.
Indications
Neomycin is primarily indicated in conditions like Decontamination of digestive tract, Hepatic coma, Hepatic encephalopathy, Pre-operative bowel sterilization, Sepsis, Skin infections, Superficial infections, and can also be given in adjunctive therapy as an alternative drug of choice in Acute bacterial enteritis, Bladder infections, Hypercholesterolaemia, Wounds management.
Contraindication
Neomycin is contraindicated in conditions like Allergy,Myasthenia gravis,Parkinsonism,Intestinal obstruction,Perforation of eardrum,Renal impairment.
Side Effects
The severe or irreversible adverse effects of Neomycin, which give rise to further complications include Urticaria, Angioneurotic edema, Ototoxicity, Blood dyscrasias, blood dyscrasias.Neomycin produces potentially life-threatening effects which include Anaphylactic shock, Renal failure, Skeletal muscle paralysis, Superinfection. which are responsible for the discontinuation of Neomycin therapy.The signs and symptoms that are produced after the acute overdosage of Neomycin include Permanent deafness.The symptomatic adverse reactions produced by Neomycin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Vertigo, Headache, Diarrhea, Tinnitus, Pruritus, Lethargy, Skin rash, Contact dermatitis, Pyuria, Steatorrhea, Azotemia, Cylindruria, Contact dermatitis.
Warnings
Neomycin should be used with caution in patients who are sensitive to aminoglycosides, renal disease or renal impairment, patients with dehydration and in elderly patients. Patient with pre-existing tinnitus, vertigo or subclinical high frequency hearing impairrment should be closely monitored for sign of ototoxicity during therapy with neomycin. Take appropriate measures in case of secondary infections. Parenteral use of neomycin or its use for irrigation of wound or serouse cartities is no longer recommended.
High Risk Groups
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Dosage
Neomycin Dosage for Adults
Dose | 4 to 12 g |
Single Dose | 8 (8) |
Frequency | 24 hourly |
Route | PO |
Note: For 5-6 days. Frequency may be increased upto 4 times if needed. | |
Dose | 0.5 % |
Single Dose | 0.5 (0.5) |
Frequency | As recommended. |
Route | Topical |
Note: 1-4 times as required. |
Neomycin Dosage for Neonatal
Dose | 0.5 % |
Single Dose | 0.5 (0.5) |
Frequency | As recommended. |
Route | Topical |
Note: As required |
Neomycin Dosage for Paedriatic
Dose | 250 to 0 mg |
Single Dose | 120 (125) |
Frequency | As recommended. |
Route | 2 or 3 days before surgery for children 6 to 12 years. |
Dose | 50 to 0 mg/kg |
Single Dose | 25 (25) |
Frequency | As recommended. |
Route | PO |
Note: In divided doses for hepatic encephalophathy. | |
Dose | 0.5 % |
Single Dose | 0.5 (0.5) |
Frequency | As recommended. |
Route | Topical |
Note: As required |
Brands
Community Contribution
Do you know any authentic drug which is not listed here? Please let us know.