Mycophenolate
Mycophenolate Information

About Mycophenolate

Mycophenolate is an immunosupressant, first isolated in 1898 from Penicillium stoloniferum. Mycophenolate is a reversible inhibitor of inosine monophosphate dehydrogenase and thus inhibits purine synthesis, with potent cytostatic effects on both T-and B-lymphocytes. Mycophenolate is used in combination with other immunosupressants, for the treatment and prevention of graft rejection and in auto-immune or immune-mediate inflammatory disease. it was approved by the FDA in May 3, 1995, for prevention of alograft rejection.

Indications

Mycophenolate is primarily indicated in conditions like Graft rejection, Pophylaxis of acute renal transplant rejection, Pophylaxis of cardiac transplant rejection, Pophylaxis of hepatic transplant rejection, Symptoms associated with carcinoid tumours.

Contraindication

Mycophenolate

Side Effects

The severe or irreversible adverse effects of Mycophenolate, which give rise to further complications include Anemia, Anemia, Thrombocytopenia, Leucopenia, Bone marrow depression, Hyperglycemia, Hypertension, Hematuria, Tremors, Hyperglycemia, Anemia, Anemia, Disturbances of electrolyte, Disturbances of blood lipids.The symptomatic adverse reactions produced by Mycophenolate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Alopecia, Diarrhea, Dyspnea, Insomnia, Pain, Cough, GI hemorrhage, GI disturbance, Alopecia, dizziness.

Warnings

It should be used with care in patients with severe renal impairment or active disorders of gastrointestinal tract. Therapy should begin as soon as possible after transplantation. Patient should undergo regular blood counts. If neutropenia develops than therapy should be stop or reducing the dose.

High Risk Groups

Drug should not be given to Pregnant Mothers, and patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.