Misoprostol
Misoprostol Information
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Misoprostol
medicine,pricing, side effects of Misoprostol medicine by company and complete information of medicines in pakistan here on this page including all packings, MG, dosage information. This list includes medicines and drugs over every region of Pakistan like Karachi, Lahore, Islamabad, Faisalabad, Rawalpindi, Multan, Peshawar, Quetta and other cities of Pakistan.About Misoprostol
Misoprostol is a synthetic, oral prostaglandin E1 analog and exists in 1:1 mixture of two diastereoisomers. Misoprostol is used for and is commonly believed to be effective for prevention of gastric and duodenal ulcers secondary to use of nonsteroidal antiinflammatory drugs (NSAIDs), although currently Misoprostol is indicated only for the prevention of gastric ulcers. While Misoprostol is approved for use in preventing NSAID-induced gastric ulcers in high-risk patients and it has been shown to be superior than sucralfate for this condition, uncertainty exists regarding the role of it in patients receiving NSAIDs. Independent of NSAID administration, it has been used as a therapeutic agent in the treatment of active duodenal and gastric ulcers, although Misoprostol is slightly less effective than H-2-antagonists. It was approved by the FDA in December 1988.it inhibits basal and nocturnal gastric acid secretion through a direct action on the parietal cell. Parietal cells contain receptors that have high affinity for prostaglandins of the E series. It can inhibit gastric acid secretion secondary to stimulation from food, alcohol, NSAIDs, histamine, pentagastrin, or caffeine, and this effect appears to be more pronounced with increasing doses. HÁ-antagonists, however, appear to be more potent than it in the ability to inhibit gastric acid output, especially at night.
Indications
Misoprostol is primarily indicated in conditions like Benign gastric and duodenal ulceration, Haemorrhage, Peptic ulcer, Prophylaxis of NSAID-induced gastric and duodenal ulceration, and can also be given in adjunctive therapy as an alternative drug of choice in Termination of pregnancy.
Contraindication
Misoprostol
Side Effects
The symptomatic adverse reactions produced by Misoprostol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Dizziness, Headache, Diarrhea, Abdominal pain, Skin rashes, Cramps, Hypotension, Nausea and vomiting, Dysmenorrhea, Hypermenorrhea, Spotting, Skin rashes, dizziness.
Warnings
Do not take misoprostol during pregnancy or lactation, because it can cause miscarriages and serious bleeding if taken during pregnancy. Before taking misoprostol, tell the doctor about taking prescription and nonprescription drugs especially antacids, aspirin and arthritis medication.
High Risk Groups
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Dosage
Misoprostol Dosage for Adults
| Dose | 200 ug |
| Single Dose | 200 (200) |
| Frequency | 6 hourly |
| Route | PO |
Misoprostol Dosage for Paedriatic
| Dose | Safety not established |
| Single Dose | |
| Frequency | |
| Route |
Brands
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