Miconazole (Nitrate)
Miconazole (Nitrate) Information

About Miconazole (Nitrate)

Miconazole (Nitrate) is imidazole-type antifungal. When miconazole was first released, it was hoped it would replace amphotericin B as a parenteral antifungal agent. It was soon discovered, however, that miconazole not only failed to offer the same efficacy as amphotericin B, but also possessed intrinsic toxicities after IV administration. While miconazole is still marketed in a parenteral formulation, it most commonly is used topically and intravaginally. Miconazole was approved by the FDA in 1974it was one of the first azole antifunfal agent to become widely used for treating mycoses. Miconazole (Nitrate) is a topically used azole. Like other azole antifungals, miconazole exerts its effect by altering the fungal cell membrane. Miconazole inhibits ergosterol synthesis by interacting with 14a demethylase, a cytochrome P-450 enzyme that is necessary for the conversion of lanosterol to ergosterol, an essential component of the membrane. Inhibition of ergosterol synthesis results in increased cellular permeability, causing leakage of cellular contents. Miconazole does not appear to have the same effect on human cholesterol synthesis.

Indications

Miconazole (Nitrate) is primarily indicated in conditions like Balanitis, Candidosis, Fungal infection, Vulvo-vaginal candidosis.

Contraindication

Miconazole (Nitrate) is contraindicated in conditions like Hypersensitivity to any component of product.

Side Effects

The severe or irreversible adverse effects of Miconazole (Nitrate), which give rise to further complications include Cardiac arrhythmias, Hepatitis, Cardiac arrhythmias, Phlebitis, Pruritis, Arachnoiditis.Miconazole (Nitrate) produces potentially life-threatening effects which include Cardiac Arrest, Cardiac arrest, Anaphylaxis. which are responsible for the discontinuation of Miconazole (Nitrate) therapy.The symptomatic adverse reactions produced by Miconazole (Nitrate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Anorexia, Rashes, GI upset, Flushing, Nausea and vomiting, Local irritation.

Warnings

Miconazole should be used cautiously during pregnancy.

High Risk Groups

Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.