Metoclopramide (HCl)
Metoclopramide (HCl) Information

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Metoclopramide (HCl)

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About Metoclopramide (HCl)

Metoclopramide (HCl) is antiemetic with dopamine antagonist action in brain and peripheral effect on gastro-intestinal tract where it stimulates motility to improve gastric emptying and intestinal transit. Metoclopramide (HCl) is used to treat nausea, and vomiting of most causesand as an adjunct to X-ray examination of the gut. Metoclopramide (HCl) is given both orally and parentrally.

Indications

Metoclopramide (HCl) is primarily indicated in conditions like Delayed gastric emptying, Diagnostic procedures, Flatulence, Gastritis, GI motality disorder, Heart burn, Hiccup in palliative care, Migraine, Nausea and vomiting, Nausea and vomiting (chemotherapy induced), Reflux oesophagitis, and can also be given in adjunctive therapy as an alternative drug of choice in Defective lactation, Hiccup due to gastric distension in palliative care, Postural hypotension, Psychosis.

Contraindication

Metoclopramide (HCl) is contraindicated in conditions like Parkinsonism,Phaeochromocytoma,Pyloric stenosis,Dystonia.

Side Effects

The severe or irreversible adverse effects of Metoclopramide (HCl), which give rise to further complications include Tardive dyskinesia, Parkinsonism, Acute dystonia, Acute porphyria, Acute dyskinesia, Extrapyramidal reactions.The signs and symptoms that are produced after the acute overdosage of Metoclopramide (HCl) include Tachycardia, Drowsiness, Dystonia.The symptomatic adverse reactions produced by Metoclopramide (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Diarrhea, Akathisia, Skin rash, Impotence, Hypotension, Gynecomastia, Galactorrhea, Hypertension, Increase in heart rate, Hyperprolactinemia, Mental disturbances, neuroleptic disorder.

Warnings

Patient should observe caution while driving or performing other tasks requiring alertness because it may produce drowsiness. Metoclopramide should be used with caution in patients with previously detected breast cancer.Children, Young adults & elderly should be treated with care as they are at increased risk of extrapyramidal reactions. Care should be taken when metoclopramide is given to pateints with renal or hepatic impairment.

High Risk Groups

Drug should not be given to patients suffering from Liver Malfunction, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Dosage

Metoclopramide (HCl) Dosage for Adults

Dose 10 to 15 mg
Single Dose 12 (12.5)
Frequency 6 hourly
Route PO,IV,IM
Note: Renal dysfunction: decrease dose.

Metoclopramide (HCl) Dosage for Neonatal

Dose 0.1 mg/kg
Single Dose 0.1 (0.1)
Frequency 8 hourly
Route Intramuscular
Dose 0.1 mg/kg
Single Dose 0.1 (0.1)
Frequency 8 hourly
Route Intravenous
Dose 0.1 mg/kg
Single Dose 0.1 (0.1)
Frequency 8 hourly
Route Oral

Metoclopramide (HCl) Dosage for Paedriatic

Dose 0.1 to 0.2 mg/kg
Single Dose 0.15 (0.15)
Frequency 8 hourly
Route Intra Muscular
Note: -
Dose 0.1 to 0.2 mg/kg
Single Dose 0.15 (0.15)
Frequency 8 hourly
Route Intra Venous
Note: -
Dose 0.1 to 0.2 mg/kg
Single Dose 0.15 (0.15)
Frequency 8 hourly
Route Oral
Note: -

Brands


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