Methionine
Methionine Information

About Methionine

Methionine is a naturally occuring amino acid. Chemically Methionine is 2-amino-4-methyl-mercaptobutyric acid. Methionine is essential constituent of diet. May be used as an antidote in severe poisoning due to Paracetamol where Methionine is thought to prevent liver demage by reducing the concentration of toxic metabolite . Natural sources of it include fish, meat, and vegetable proteins. Given orally it causes few side effects, principally nausea. Must not be given more than ten hours after the over dosage as it may then exacerbate liver demage. .

Indications

Methionine is primarily indicated in conditions like Amino acid deficiency, Diaper rash, Incontinence, Paracetamol overdosage, Paracetamol poisoning.

Contraindication

Methionine is contraindicated in conditions like Acidosis,Chronic liver disease,Schizophrenia.

Side Effects

Methionine produces potentially life-threatening effects which include Encephalopathy. which are responsible for the discontinuation of Methionine therapy.The signs and symptoms that are produced after the acute overdosage of Methionine include Hypotension, Disorientation, Nausea, Vomiting, Fever.The symptomatic adverse reactions produced by Methionine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Irritability, Nausea, Vomiting.

Warnings

Methionine should be used with caution in patients with severe liver diseases. Methionine should not be given to patients with acidosis.

High Risk Groups

Drug should not be given to patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.