Metformin (HCl)
Metformin (HCl) Information

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Metformin (HCl)

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About Metformin (HCl)

Metformin (HCl) is oral biguanide antidiabetic agent, introduced in 1950s. It reduces elevated blood glucose concentration in diabetic patients, but it does not increase insulin secretion. Metformin (HCl) is used alone or in combination with insulin or chlorpropamide. Most useful in overweight subjects, where it supresses appetite. May cause nausea, vomiting and diarrhoea.

Indications

Metformin (HCl) is primarily indicated in conditions like Diabetes mellitus, Hyperlipoproteinaemia, Insulin dependent diabetes mellitus, Insulin resistance, Non-insulin dependent diabetes mellitus, Obesity.

Contraindication

Metformin (HCl) is contraindicated in conditions like Alcohol dependence,Anaemia,Myocardial infarction,Septicaemia,Infections,Respiratory disease,Ketosis,Cardiovascular disease,Diabetic coma,Trauma,Liver damage,Iron deficiency,Vitamin B12 deficiency,Renal impairment,Diabetic retinopathy.

Side Effects

The severe or irreversible adverse effects of Metformin (HCl), which give rise to further complications include Vasculitis, Pneumonitis, Malabsorption of vit B12, Malabsorpton of folic acid, Megaloblastic anemia, Hypoglycemia.Metformin (HCl) produces potentially life-threatening effects which include Lactic Acidosis. which are responsible for the discontinuation of Metformin (HCl) therapy.The symptomatic adverse reactions produced by Metformin (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Abdominal distension, Flatulence, Nausea, Vomiting, Anorexia, Diarrhea, Skin reactions, Weight LossX, Hypersensitivity, Metallic taste.

Warnings

Metformin should be used with caution in patients with pre-existing liver disease, kidney disease, heart trouble or if have any allergy, infections. Avoid excessive use of alcohol while taking this. It is not recommended for use during pregnancy and should be used only if clearly needed during lactation.

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Dosage

Metformin (HCl) Dosage for Adults

Dose 500 to 3000 mg
Single Dose 1800 (1750)
Frequency 12 hourly
Route PO
Note: Frequency may be increased upto 3times/day, if needed. Gradually increase upto 2-3 g/day.

Metformin (HCl) Dosage for Paedriatic

Dose
Single Dose
Frequency
Route
Note: Not recommended in this age group

Brands


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