Mepyramine
Mepyramine Information

About Mepyramine

Mepyramine is a first generation antihistamine targetting H1 receptor.It is an ethylenediamine derivative and is a sedating anti-histamine with antimuscarinic and sedative properties. Mepyramine (Maleate) is used for the symptomatic relief of hypersensitivity reaction and in pruritic skin disorders.

Indications

Mepyramine is primarily indicated in conditions like Allergy, Cold, Cough, Hypersensitivity reactions, Pruritus.

Contraindication

Mepyramine is contraindicated in conditions like Asthma,Cardiac disease,Urinary retention,Angle-closure glaucoma,Renal impairment,Hepatic impairment.

Side Effects

The severe or irreversible adverse effects of Mepyramine, which give rise to further complications include Hallucinations, Hair loss, Ataxia, Cardiac arrhythmias, Rashes, Bronchospasm, Angioedema, CNS depression, Psychosis, Palpitation, Urinary retention, Myalgia, Tremors, Blood disorders, Anaphylaxis.Mepyramine produces potentially life-threatening effects which include Coma, Convulsions, Cardiorespiratory collapse. which are responsible for the discontinuation of Mepyramine therapy.The signs and symptoms that are produced after the acute overdosage of Mepyramine include Convulsions, Coma, Ataxia, Hyperpyrexia, Tremor, Extrapyramidal effects, Excitement.The symptomatic adverse reactions produced by Mepyramine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Excitement, Fever, Constipation, Dry mouth, Blurred vision, Rashes, Nausea and vomiting, Lassitude, Incoordination.

Warnings

Patients should observed caution while driving or performing other tasks requiring alertness, because may cause drowsiness. Mepyramine should be used with caution in patients with liver impairment, dose should be reduced in patients with renal impairment. Avoid use in young children and use with caution in elderly patients. Topical preparation containing antihistamines should not be used on broken and eczematous skin.

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.