Medroxyprogesterone (Acetate)
Medroxyprogesterone (Acetate) Information

About Medroxyprogesterone (Acetate)

Medroxyprogesterone (Acetate) is oral and parenteral synthetic progestin a (sex hormone). Medroxyprogesterone (Acetate) is 15 times more potent than progesterone. Can be used for the treatment of amenorrhea, abnormal uterine bleeding, endometriosis secondary to hormonal imbalances, and endometrial and renal cell carcinomas. The IM injection is a sustained-release (i.e., "depo") product available in 2 dosage strengths: one for use as a contraceptive and the other for the treatment of endometrial and renal cell carcinoma.it may be useful as respiratory stimulants in certain pulmonary disorders such as chronic obstructive pulmonary disease (COPD). it was approved by the FDA in 1959. The primary contraceptive effect of progestins involves the suppression of the midcycle surge of LH. The exact mechanism of action, however, is unknown. At the cellular level, progestins diffuse freely into target cells and bind to the progesterone receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH surge, thereby preventing follicular maturation and ovulation. Overall, progestin-only contraceptives prevent ovulation in 70-80% of cycles.

Indications

Medroxyprogesterone (Acetate) is primarily indicated in conditions like Adjunctive treatment of endometrial carcinoma, Adjunctive treatment of renal carcinoma, Breast cancer, Contraception, Dysfunctional uterine bleeding, Endometrial cancer, Endometriosis, Mild to moderate endometriosis, Progestogenic opposition of oestrogen hrt, Secondary amenorrhoea, Uterine bleeding, and can also be given in adjunctive therapy as an alternative drug of choice in Pelvic congestion, Renal carcinoma.

Contraindication

Medroxyprogesterone (Acetate) is contraindicated in conditions like Hepatic dysfunction,Hypersensitivity,Abnormal uterine bleeding,Phlebitis,Hematuria.

Side Effects

The severe or irreversible adverse effects of Medroxyprogesterone (Acetate), which give rise to further complications include Urticaria, Impotence, Jaundice, Increased blood pressure, Thrombophlebitis, Hyperglycemia, Hypertension, Depression, Pulmonary embolism, Retinal thrombosis, Myalgia, Decreased libido, Breakthrough bleeding, Thromboembolism.Medroxyprogesterone (Acetate) produces potentially life-threatening effects which include Anaphylactoid reactions. which are responsible for the discontinuation of Medroxyprogesterone (Acetate) therapy.The symptomatic adverse reactions produced by Medroxyprogesterone (Acetate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Alopecia, Diarrhea, Anxiety, Insomnia, Abdominal pain, Termors, Weight LossX, SweatingX, Weight gain, Elevation of liver enzymes, Muscle cramps, Fluid retention, Acne, Hirsutism, Amenorrhea, Anovulation, Vaginal spotting, Cushing syndrome, Dysmenorrhea, Reaction at injection site, Cervicitis, Appetite stimulation.

Warnings

Medroxyprogesterone acetate should be used with caution in patients with any allergy (especially drug allergies), abnormal vaginal bleeding, liver, kidney or heart disease, missed abortion, blood clots, seizures, migraine, asthma, depression or diabetes. Limit alcohol, as this may increase side effects of this drug. It is not recommended to take it in early pregnancy.

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.