Loperamide (HCl)
Loperamide (HCl) Information

About Loperamide (HCl)

Loperamide (HCl) is antidiarrheal agent. Loperamide (HCl) is chemically related to haloperidol, acting diractly on the intestinal wall o inhibit paristalsis. It acts mora rapidly and is longer acting than diphenoxylate and cogeine. Loperamide (HCl) is also effective to reduce the amount of discharge from ileostomies. Loperamide (HCl) is prepared by chemical synthesis. Loperamide (HCl) is administered orally.

Indications

Loperamide (HCl) is primarily indicated in conditions like Acute diarrhoea, Chronic diarrhoea in adults, Control of agitated states in elderly without confusion, Diarrhoea, The pain of bowel colic in palliative care.

Contraindication

Loperamide (HCl) is contraindicated in conditions like Acute dysentry.

Side Effects

The signs and symptoms that are produced after the acute overdosage of Loperamide (HCl) include Constipation, Somnolence, Bradypnea, Muscular hypertonia, Neurological symptoms, Ileus.The symptomatic adverse reactions produced by Loperamide (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Drowsiness, Fatigue, Nausea, Vomiting, Skin reactions, Abdominal cramps, Urticaria, dizziness.

Warnings

Discontinue Loperamide if clinical improvement is not observed in 48hrs.in case of acute diarrhea. Monitor patients with hepatic (liver) dysfunction for sign of CNS toxicity. Loperamide should not be used in diarrhea caused by poisoning, pseudomembranous colitis and infection with enterotoxin-producing bacteria.

High Risk Groups

Drug should not be given to Pregnant Mothers, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.