Linezolid
Linezolid Information
Find all the information of Linezolid medicine and drugs available in Pakistan. Read the pricing, side effects, usage, instructions and dosage of Linezolid by .
Linezolid
medicine,pricing, side effects of Linezolid medicine by company and complete information of medicines in pakistan here on this page including all packings, MG, dosage information. This list includes medicines and drugs over every region of Pakistan like Karachi, Lahore, Islamabad, Faisalabad, Rawalpindi, Multan, Peshawar, Quetta and other cities of Pakistan.About Linezolid
Linezolid is a synthetic antibacterial, belongs to oxazolidinone class. Linezolid is active against gram +ve bacteria including staphylococci. streptococci, enterococci, gram +ve anaerobic cocci, and gram +ve rods. It has poor activity against gram -ve aerobic and anaerobic organisms. Linezolid is bacteriostatic against enterococci and staphylococci and bactericidal against streptococci. It produces its action by inhibiting protein synthesis within the bacterial cell. Linezolid is used in the treatment of infections caused by vancomycin-resistant E. faecium; nosocomial pneumonia caused by methicillin-susceptible and resistant strains of S. aureus, and complicated skin and soft tissue infections caused by gram +ve bacteria.
Indications
Linezolid is primarily indicated in conditions like Pneumonia, Respiratory tract infections, Severe or recurrent duodenal and gastric ulcertion, Skin infections.
Contraindication
Linezolid is contraindicated in conditions like Breast feeding.
Side Effects
The severe or irreversible adverse effects of Linezolid, which give rise to further complications include Convulsions, Stevens johnson syndrome, Stevens johnson syndrome, Leucopenia, Pancytopenia, Abnormal liver function, Anaemia, Lactic acidosis.The symptomatic adverse reactions produced by Linezolid are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Diarrhea, Fever, Constipation, Insomnia, Tinnitus, Dry mouth, Rashes, Urticaria, Pruritus, Hypotension, Nausea and vomiting, Tongue discoloration, Neuropathy, Dry mouth, dizziness.
Warnings
Linezolid should be used with caution in patients with hepatic impairment; renal impairment; pregnancy (use only if potential benefit outweighs risk); monitor full blood count (including platelet count) weekly uless close observation and blood-pressure monitoring possible, avoid in uncontrolled hypertension, phaeocytochroma, carcinoid tumour, thyrotoxicosis, bipolar depression, schizophrenia, or acute confusional states. Monoamine Oxidase Inhibition: Linezolid is a reversible, non-selective monoamine oxidase inhibitor (MAOI). Patients should avoid consuming large amounts of tyramine-rich foods (such as mature cheese, yeast extracts, undistilled alcoholic beverages and fermented soya bean products). In addition, Linezolid should not be given with another MAOI or within two weeks of stopping another MAOI.Unless close observation and blood-pressure monitoringis possible, avoid in those receiving SSRIs, 5HT1 agonists (triptans), tricyclic antidepressants, sympathomimitics, dopaminergics, buspirone, pethidine and possibly other opiod analgesics.
High Risk Groups
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Dosage
Linezolid Dosage for Paedriatic
| Dose | 10 mg/kg |
| Single Dose | 10 (10) |
| Frequency | 8 hourly |
| Route | Orally |
Brands
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