Ketoprofen
Ketoprofen Information

About Ketoprofen

Ketoprofen is NSAID (non-steroidal anti-inflammatory drug). Ketoprofen is a propionic acid derivative and widely used in the treatment of pateints with rheumatic diseases. It reduces fever, inflammation or swelling and relieves pain. Ketoprofen is used to treat pain, swelling and stiffness associated with arthritis. Ketoprofen is also used to treat headaches, muscle aches and dental pain. Ketoprofen is available for oral, rectal, parentral and topical administration. Chemically Ketoprofen is (R, S)-2-(3-benzoylpheny) propionicacid. It inhibits cyclooxygenase actvity with reduction in the tissue production of prostaglandins such as PGE-2 and PGF-2a

Indications

Ketoprofen is primarily indicated in conditions like Ankylosing spondylitis, Bursitis, Gastro-oesophageal reflux disease, Gout, Lumbago, Management of cushing"s syndrome, Musculoskeletal disorders, Osteoarthritis, Pain, Rheumatic diseases, Rheumatoid arthritis, Synovitis, Tendinitis, Tenosynovitis, and can also be given in adjunctive therapy as an alternative drug of choice in Dental pain, Dysmenorrhoea, Fever, fever, Infections, Migraine, Orthopedic manipulations.

Contraindication

Ketoprofen is contraindicated in conditions like Peptic ulcer,Bronchospasm,Rhinitis,Renal insufficiency.

Side Effects

The severe or irreversible adverse effects of Ketoprofen, which give rise to further complications include Reduced GFR (glomerular filtration rate), Acute interstitial nephritis, Platelet dysfunction.Ketoprofen produces potentially life-threatening effects which include Gastrointestinal hemorrhage. which are responsible for the discontinuation of Ketoprofen therapy.The signs and symptoms that are produced after the acute overdosage of Ketoprofen include Hypotension, Vomiting, Bronchospasm, Drowsiness, Abdominal pain, GI hemorrhage.The symptomatic adverse reactions produced by Ketoprofen are more or less tolerable and if they become severe, they can be treated symptomatically, these include Vertigo, Nausea, Vomiting, Diarrhea, Constipation, Photosensitivity, Skin rash, Dyspepsia, GI upset, Bullous rash, dyspepsia, Gastric pain.

Warnings

Ketoprofen should be used with caution in patients with intrinsic coagulation defects and those on anticoagulant therapy. It should be used with caution in patients with compromised cardiac function, hypertension other condition predisposing to fluid retention. It should be used with extra care in the presence of existing controlled infection. Perform periodic auditory (hearing) function test during chronic therapy. Discontinue drug if skin reaction occurs. Ketoprofen is not recommended in the patient who have experienced a severe Aspirin hypersensitivity reactions. IM injection should be administered cautiouly to patient receiving ketoprofen.

High Risk Groups

Drug should not be given to patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.