Kanamycin (Acid Sulphate)
Kanamycin (Acid Sulphate) Information

About Kanamycin (Acid Sulphate)

Bactericidal aminoglycoside antibiotic (the aminoglycosides are the compound containing characteristic amino sugars joined to a hexose nucleus in glycoside linkage, they are polycations and their polarity accounts for their pharmakokinetic peoperties). Kanamycin (Acid Sulphate) is derived from Streptomyces kanamyceticus, consisting of three components designated A, B and C. The clinically active form is a mixture of kanamycins A and B. Kanamycin has actions and spectrum similar to Neomycin, but less ototoxic. Used in gram -ve speticaemia, with monitoring of blood levels, perticularly in renal failure. Kanamycin (Acid Sulphate) is most often applied topically.

Indications

Kanamycin (Acid Sulphate) is primarily indicated in conditions like Bacterial infections, Enteritis, Gonorrhoea, Hepatic encephalopathy, Meningitis, Septicaemia, Tuberculosis, Urinary tract infection, and can also be given in adjunctive therapy as an alternative drug of choice in Superficial infections.

Contraindication

Kanamycin (Acid Sulphate) is contraindicated in conditions like Neuromuscular blockade.

Side Effects

The severe or irreversible adverse effects of Kanamycin (Acid Sulphate), which give rise to further complications include Nephrotoxicity, Ototoxicity, Eosinophilia, Eosinophilia.Kanamycin (Acid Sulphate) produces potentially life-threatening effects which include Neuromuscular blockage. which are responsible for the discontinuation of Kanamycin (Acid Sulphate) therapy.The signs and symptoms that are produced after the acute overdosage of Kanamycin (Acid Sulphate) include 8th nerve damage.The symptomatic adverse reactions produced by Kanamycin (Acid Sulphate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Vertigo, Headache, Nausea, Vomiting, Diarrhea, Tinnitus, Local pain, Circumoral paresthesia, Bruising, Bruising.

Warnings

Kanamycin should be used with caution in patients with history of kidney diseases gasteointertinal ulceration, vertigo, hearing loss, mysthenia gravis, parkinsonisms.It should be used with caution in patients who are sensitive to aminoglycosides. Keep patients well hydrated to prevent chemical irritation or nephrotoxic reactions. Take appropriate measures in case of secondry infections.

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.