Isoniazid
Isoniazid Information
Find all the information of Isoniazid medicine and drugs available in Pakistan. Read the pricing, side effects, usage, instructions and dosage of Isoniazid by .
Isoniazid
medicine,pricing, side effects of Isoniazid medicine by company and complete information of medicines in pakistan here on this page including all packings, MG, dosage information. This list includes medicines and drugs over every region of Pakistan like Karachi, Lahore, Islamabad, Faisalabad, Rawalpindi, Multan, Peshawar, Quetta and other cities of Pakistan.About Isoniazid
Isoniazid is the hydrazide of isonicotinic acid.Isoniazid is structurally similar to pyridoxine and introduced in 1952. It is the most active drug for the treatement of tuberculosis caused by susceptible strains used either alone or in combination with other drugs. It is prepared by chemical synthesis. It is available in combination with pyrazinamide, rifampicin, ethambutol, pyridoxine and cyanocobalamine.
Indications
Isoniazid is primarily indicated in conditions like Acute leukemia, Mycobacterial infection, Prophylaxis of TB, Tuberculosis, Vestibular disorders, and can also be given in adjunctive therapy as an alternative drug of choice in Pulmonary TB.
Contraindication
Isoniazid is contraindicated in conditions like Diabetes mellitus,Hypersensitivity,Seizures.
Side Effects
The severe or irreversible adverse effects of Isoniazid, which give rise to further complications include Hepatotoxicity, Pancreatitis, Lupus erythematosus, Peripheral neuropathy, Hepatotoxicity, Gynecomastia, Increase liver enzyme.Isoniazid produces potentially life-threatening effects which include Hepatitis. which are responsible for the discontinuation of Isoniazid therapy.The signs and symptoms that are produced after the acute overdosage of Isoniazid include Nausea, Vomiting, Tachycardia, Convulsions, Coma, Seizures, Urinary retention, Dizziness, Hyperreflexia, Slurred speech.The symptomatic adverse reactions produced by Isoniazid are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Diarrhea, Fever, Skin rashes, Skin eruptions, Vasculitis, Skin eruptions, Skin rashes.
Warnings
Minimize alcohol consumption while taking isoniazid, because alcohol can reduce the effectiveness of this medication and increase side effect. It should be used with caution if patients have been treated for tuberculosis before, have kidney or liver problems, diabetes, history of alcohol use and of any drug allergy. Tyramine and histamine-containing foods may rarely interact with this medication, these foods include large amounts of fish, cheese, yeast extract or sausages. Consult the doctor or pharmacist immediately if patient suffer from flushing or a rapid heart beat. It should be used during pregnancy or lactation only if clearly needed.
High Risk Groups
Drug should not be given to patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Dosage
Isoniazid Dosage for Adults
| Dose | 300 mg |
| Single Dose | 300 (300) |
| Frequency | 24 hourly |
| Route | PO |
| Note: Give 30 min. before breakfast for 2 months. |
Isoniazid Dosage for Neonatal
| Dose | 10 to 15 mg/kg |
| Single Dose | 12 (12.5) |
| Frequency | 24 hourly |
| Route | Intavenous |
| Dose | 10 to 15 mg/kg |
| Single Dose | 12 (12.5) |
| Frequency | 24 hourly |
| Route | Intramuscular |
| Dose | 10 to 15 mg/kg |
| Single Dose | 12 (12.5) |
| Frequency | 24 hourly |
| Route | Oral |
Isoniazid Dosage for Paedriatic
| Dose | 15 mg/kg |
| Single Dose | 15 (15) |
| Frequency | 24 hourly |
| Route | Intra Muscular |
| Note: Single Dose | |
| Dose | 10 mg/kg |
| Single Dose | 10 (10) |
| Frequency | 24 hourly |
| Route | Intra Venous |
| Note: Single Dose | |
| Dose | 10 mg/kg |
| Single Dose | 10 (10) |
| Frequency | 24 hourly |
| Route | Oral |
| Note: Single Dose |
Brands
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