Hydroxyprogesterone
Hydroxyprogesterone Information

About Hydroxyprogesterone

Hydroxyprogesterone is intermediate formed in the conversion of cholesterol to cortisol, androgen and estrogens, used in contraception (to prevent pregnancy). Hydroxyprogesterone is also used to treat dysmenorrhea, irregular uterine bleeding and in the management of endometriosis.

Indications

Hydroxyprogesterone is primarily indicated in conditions like Abortion prevention, Habitual abortion, Preterm labour, and can also be given in adjunctive therapy as an alternative drug of choice in Endometrial cancer.

Contraindication

Hydroxyprogesterone is contraindicated in conditions like Breast cancer,Vaginal bleeding,Hyperlipidemia,Liver carcinoma.

Side Effects

The severe or irreversible adverse effects of Hydroxyprogesterone, which give rise to further complications include Allergic reaction chest pain pepression.The symptomatic adverse reactions produced by Hydroxyprogesterone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Diarrhea, Local pain, GI upset, Weight gain, Edema, Pre-existing acne & urticaria.

Warnings

Hydroxyprogesterone should not be used during pregnancy or lactation. It should be used with caution in patients with any pre-existing liver disease, diabetes, seizure disorder, kidney disease, heart trouble, asthma or a history of depression, migraines, blood clots, miscarriage or breast cancer or any allergy. Because this medication may increase sensitivity to sunlight, avoid prolonged sun expose, wear a sunscreen and protective clothing when outdoors. Diabetic patients should monitor urine and blood sugar closely while taking this medication as it can reduce glucose tolerance.

High Risk Groups

Drug should not be given to Paediatrics, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.