Heparin (Na) and Heparin (Cl)
Heparin (Na) and Heparin (Cl) Information

About Heparin (Na) and Heparin (Cl)

Heparin (Na) and Heparin (Cl) is anticoagulant agent. Heparin (Na) and Heparin (Cl) is a highly negatively charged heterogeneous mixture of sulfated mucopolysaccharide, varying in the molecular weights and composed of polymer of alternating derivatives of D-glucosamine and L-iduronic acid or D-glucuronic acid, having the property of prolonging the clotting time of blood. Heparin is the body's natural anticoagulant. Heparin (Na) and Heparin (Cl) is usually obtained from the lungs, intestinal mucosa or other suitable tissue of domestic mammals used for food by man. Heparin is employed clinically in conditions in which a rapid reduction in the coagulation ability of blood is desired. Heparin calcium and heparin sodium are the calcium and sodium salts of active principles that compose heparin. Heparin calcium and sodium are administered intravenously or subcutaneously.

Indications

Heparin (Na) and Heparin (Cl) is primarily indicated in conditions like Analgesia, Angina, Consumptive thrombohemorrhagic disorders, Deep vein thrombosis, During pregnancy, Maintenance of light anaesthesia, Metastatic germ cell cancers (seminoma and teratoma), Myocardial infarction, Prophylaxis of thrombosis, Pulmonary embolism, Treatment of deep-vein thrombosis and pulmonary embolism.

Contraindication

Heparin (Na) and Heparin (Cl) is contraindicated in conditions like Subarachnoid haemorrhage,Renal failure,Haemostatic defect,Hepatic failure,Cerebral hemorrhage,Arterial thrombosis,Wounds,Abdominal bleeding.

Side Effects

The severe or irreversible adverse effects of Heparin (Na) and Heparin (Cl), which give rise to further complications include Osteoporosis, Skin necrosis, Hypoaldosteronism.Heparin (Na) and Heparin (Cl) produces potentially life-threatening effects which include Thrombocytopenia, Bleeding. which are responsible for the discontinuation of Heparin (Na) and Heparin (Cl) therapy.The signs and symptoms that are produced after the acute overdosage of Heparin (Na) and Heparin (Cl) include Bleeding.The symptomatic adverse reactions produced by Heparin (Na) and Heparin (Cl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Urticaria, Rhinitis, Conjunctivitis, Asthma, Cyanosis, Oppressive feelings, Angioedema, Anaphylactic shock, Tachypnea, Delayed-type hypersensitivity.

Warnings

Heparin should be used with caution in presence of mild kidney or liver disease,patients of diabetes,hypertension,in women over 60 yrs.of age.If the coagulation test is prolonged or hemorrhages occur then discontinue the drug. Heparinoids should be used with caution in patients hypertension, stroke, hemorrhage, bleeding, thrombocytopenia associated with positive invitro test for antiplatelet antibody in presence of danaparoid.

High Risk Groups

Drug should not be given to Paediatrics, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.