Glyceryl Trinitrate
Glyceryl Trinitrate Information

About Glyceryl Trinitrate

Glyceryl Trinitrate is a vasodialator (expands the blood vessels) Glyceryl Trinitrate is used for syptomatic treatment of angina to treat cardiac failure and during hypotensive or cardiac surgery to prevent myocardial infarction.

Indications

Glyceryl Trinitrate is primarily indicated in conditions like Anal fissure, Angina pectoris, Cardiac failure, Cardiopulmonary oedema, Long-term treatment of healed reflux oesophagitis, Moderate to severe reflux oesophagitis, Myocardial infarction, Oesophageal spasm, Oesophageal spasm, Postoperative hypertension, Prinzmetal's angina, Prophylaxis of angina, Unstable angina.

Contraindication

Glyceryl Trinitrate is contraindicated in conditions like Glucoma,Hypovolaemia,Cardiac temponade,Cardiomyopathy,Cor pulmonale,Mitral valve prolapse,Raised intracranial pressure.

Side Effects

The severe or irreversible adverse effects of Glyceryl Trinitrate, which give rise to further complications include Tachycardia, Bradycardia, Collapse.The signs and symptoms that are produced after the acute overdosage of Glyceryl Trinitrate include Hypotension, Flushing, Tachycardia, Coma, Palpitations, Metabolic acidosis, Headache, Cardiovascular collapse, Syncope, Neurologic deficit, Methemoglobinemia, Increased intracranial pressure, Hypoxia, Cyanosis.The symptomatic adverse reactions produced by Glyceryl Trinitrate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Dizziness, Headache, Nausea, Vomiting, Restlessness, Palpitation, Abdominal pain, VertigoX, Urinary incontinence, Contact dermatitis, Syncope, Fecal incontinence, Orthostatic hypotension, dizziness.

Warnings

Excessive use of glyceryl trinitrate may cause headache, so reduce the dose & use analgesics (painkiller). Patients with gastrointestinal (GI) hypermotality or malabsorption syndrome should take oral or sublingual sustained release capsules rather than tablets. In terminating treatment of angina, gradually reduced the dose in order to avoid withdrawal reactions. It should not be used in patients with severe hypotension, hypovolaemia marked anemia, heart failure due to obstruction, raised intracranial pressure or angle closure glaucoma. It should be used with caution in patients with impaired kidney or liver function or hypothyroidism.Hypothermia, cereberovascular disease disease lung disease, lung desease or cor pulmonole pregnancy,lactation mitral value prolopre syncope.

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.