Glibenclamide
Glibenclamide Information

About Glibenclamide

Glibenclamide is a oral hypoglycemic agent. Glibenclamide is used in the treatment of non-insulin dependent diabetes. Glibenclamide is used in conjunction with proper diet and exercise to decrease blood sugar levels.

Indications

Glibenclamide is primarily indicated in conditions like Non-insulin dependent diabetes mellitus, Softening and dilatation of cervix before mechanical cervical dilatation.

Contraindication

Glibenclamide is contraindicated in conditions like Renal failure,Liver diseases,Diabetic coma,Impaired renal function,Insulin dependent diabetes mellitus.

Side Effects

The severe or irreversible adverse effects of Glibenclamide, which give rise to further complications include Thrombocytopenia, Cholestatic jaundice, Aplastic anemia, Hemolytic anemia, Cholestatic jaundice, Aplastic anemia, Hemolytic anemia, Leucopenia, Agranulocytosis, Pancytopenia, Hemolytic anemia, Aplastic anemia.Glibenclamide produces potentially life-threatening effects which include Hypersensitivity reactions, Renal failure, Hypoglycemia, Hypoglycemia, Hypoglycemia, Pneumonia. which are responsible for the discontinuation of Glibenclamide therapy.The signs and symptoms that are produced after the acute overdosage of Glibenclamide include Coma, Hypoglycemia, Cerebral damage.The symptomatic adverse reactions produced by Glibenclamide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, GI upset, Heart burn, Allergic skin reactions, Hepatitis, Hypoglycemia.

Warnings

During treatment with glibenclamide, compliance to diet and regular tablet intake are of utmost importance to preserve the efficacy of treatment and to avoid unwanted changes in the blood sugar levels. Hypoglycemic reactions may provoked by overdosage of glibenclamide, interacting drugs , dietary errors (omitting meals), the signs of it being headache, irritability, restlessness, profuse sweating, insomnia, tremor, impairment of performence and alertness, such hupoglycemic episodes are nearly always promptly relieved by the intake of sugar.

High Risk Groups

Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.