Gentamicin
Gentamicin Information

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Gentamicin

medicine,pricing, side effects of Gentamicin medicine by company and complete information of medicines in pakistan here on this page including all packings, MG, dosage information. This list includes medicines and drugs over every region of Pakistan like Karachi, Lahore, Islamabad, Faisalabad, Rawalpindi, Multan, Peshawar, Quetta and other cities of Pakistan.

About Gentamicin

Gentamycin is an aminoglycoside antibiotic isolated from Micromonospore purpurea. The aminoglycosides are the compound containing characteristic amino sugars joined to a hexose nucleus in glycoside linkage. Aminoglycosides are polycations and their polarity accounts for their pharmakokinetic properties. Gentamycin is effective against both gram positive and gram negative bacteria. Gentamicin (Sulphate) is active alone but also exibit synergism with ß lactam antibiotic. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Gentamicin (Sulphate) is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.

Indications

Gentamicin is primarily indicated in conditions like Acute diarrhoea, Bacterial infections, Biliary tract infections, Endocarditis, Food allergy, Muscle relaxation (intermediate duration) during intensive care, Muscle relaxation (intermediate duration) for surgery or intubation, Muscle relaxation (long duration) during intensive care, Pneumonia in hospital patients, Septicaemia, Ulcerative colitis and crohn's disease, Urinary tract infection, and can also be given in adjunctive therapy as an alternative drug of choice in Solid tumor.

Contraindication

Gentamicin is contraindicated in conditions like Renal diseases,Hypersensitivity.

Side Effects

The severe or irreversible adverse effects of Gentamicin, which give rise to further complications include Encephalopathy, Convulsions, Hallucinations, Nephrotoxicity, Hallucinations, Neuromuscular blockage, Peripheral neuritis, Anaemia.Gentamicin produces potentially life-threatening effects which include Neuromuscular blockage, Nephrotoxicity, Ototoxicity. which are responsible for the discontinuation of Gentamicin therapy.The symptomatic adverse reactions produced by Gentamicin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Vertigo, Fever, Ototoxicity, Skin rashes, Exfoliative dermatitis, Eosinophilia, Purpura, Angioedema, Pyuria, Proteinuria, Azotemia, Cylindruria, Local allergies, Skin rashes, Cross sensitivity, dizziness.

Warnings

Gentamicin should be used with caution in patients with history of kidney diseases, vertigo, hearing loss, myasthenia gravis, parkinsonisms. It should be used with caution in patients who are sensitive to aminoglycosides. Keep patients well hydrated to prevent chemical irritation or nephrotoxic reactions. Take appropriate measures in case of secondary infections.

High Risk Groups

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Dosage

Gentamicin Dosage for Adults

Dose 4 to 8 mg
Single Dose 6 (6)
Frequency As recommended.
Route Intra Thecal
Note: As Required
Dose 3 to 5 mg/kg
Single Dose 4 (4)
Frequency As recommended.
Route IV,IM
Note: In 3-4 divided doses for 7-10 days. Doses vary according to indication.
Dose 0.3 %
Single Dose 0.3 (0.3)
Frequency 6 hourly
Route Otic
Note: 1-2 drops
Dose 1.5 mg/kg/dose
Single Dose 1.5 (1.5)
Frequency As recommended.
Route PO
Note: For prevention of becterial endocarditis. NOT to exceed 80 mg with ampicillin (1-2g). 30 minutes prior to procedures.
Dose 0.3 %
Single Dose 0.3 (0.3)
Frequency 8 hourly
Route Topical
Note: Or twice a day if needed.

Gentamicin Dosage for Neonatal

Dose 2.5 mg/kg
Single Dose 2.5 (2.5)
Frequency 8 hourly
Route Intramuscular
Dose 2.5 mg/kg
Single Dose 2.5 (2.5)
Frequency 8 hourly
Route Intravenous
Dose 0.3 %
Single Dose 0.3 (0.3)
Frequency 6 hourly
Route Topical

Gentamicin Dosage for Paedriatic

Dose 0.3 %
Single Dose 0.3 (0.3)
Frequency 6 hourly
Route Ear
Note: -
Dose 2 to 1.5 mg/kg
Single Dose 1.8 (1.75)
Frequency 8 hourly
Route Intra Muscular
Dose 2.5 mg/kg
Single Dose 2.5 (2.5)
Frequency 8 hourly
Route Intra Venous
Note: -
Dose 0.3 %
Single Dose 0.3 (0.3)
Frequency 6 hourly
Route Opthalmic
Note: -
Dose 0.3 %
Single Dose 0.3 (0.3)
Frequency 6 hourly
Route Topical
Note: -

Brands


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