Estriol
Estriol Information

About Estriol

Estriol is a naturally occuring oestrogen with actions and uses similar to those of oestradiol. Estriol is claimed to have a mild proliferative effect on endometrium. Estriol is used for menopausal hormone replacement therapy (HRT). Estriol is used intravaginally for the short-term treatment of menopausal atrophic vaginitis as acream or as pessaries.

Indications

Estriol can be given in adjunctive therapy as an alternative drug of choice in Infertility, Vaginitis.

Contraindication

Estriol is contraindicated in conditions like Pregnancy,Breast feeding.

Side Effects

The symptomatic adverse reactions produced by Estriol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Vomiting, Abdominal cramps, Breast enlargement, Weight changes, Sodium and fluid retention.

Warnings

Prolonged exposure to unopposed oestrogens may increase risk of developing endometrial cancer; migraine (or migraine like headaches); interrupt treatment periodicaally to assess need for continued treatment; diabetes (increased risk of heart disease); history of breast nodulesor fibrocystic disease; closely monitor breast status; risk factors for oestrogen-dependent tumours (e.g breast-cancer in first degree relative); uterine fibroids may increase in size, symptoms of endometriosis may be exacerbated; factors predisposing to thromboembolism; presence of phospholipid antibodies (increased risk of thrombotic events).

High Risk Groups

Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.