Estradiol
Estradiol Information

About Estradiol

Estradiol is a naturally occuring sex hormone (oestrogen). estradiol is used along with progesterone for contraception, menstrual disorder, and for the suppression of certain cancers and also for the prevention of osteoporosis.

Indications

Estradiol. is primarily indicated in conditions like Menopausal symptoms, Prostatic cancer.

Contraindication

Estradiol. is contraindicated in conditions like Hypertension,Vaginal bleeding,Porphyrias,Cardiovascular disease,Oestrogenic sarcoma,Cerebrovascular disease,Haemoglobinopathies,Hyperlipoproteinaemia.

Side Effects

The severe or irreversible adverse effects of Estradiol., which give rise to further complications include Irritability, Gynacomastia, Uterine bleeding, Tachyphylaxis.Estradiol. produces potentially life-threatening effects which include Breast cancer, Endometrial carcinoma. which are responsible for the discontinuation of Estradiol. therapy.The symptomatic adverse reactions produced by Estradiol. are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Depression, Weight gain, Nausea and vomiting, Fluid retention, Breast tenderness.

Warnings

High doses of estrogen used in treatment of malignant disease should be used cautiously in patients with cerebrovascular disorder, coronary artery disease or venous thromboembolism. Estrogens should be used with caution in children, because premature closure of epiphysis may occur resulting in inhibited linear growth and small stature.

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.