Ergotamine (Tartrate)
Ergotamine (Tartrate) Information

About Ergotamine (Tartrate)

Ergotamine (Tartrate) is alkaloid derived from ergot, consisting of lysergic acis, ammonia, proline, phenylalanine and pyruvic acid combined in amide linkages. Ergotamine (Tartrate) is used as an analgesic in the treatment of migraine and cluster headaches.

Indications

Ergotamine (Tartrate) is primarily indicated in conditions like Migraine, Prophylactic treatment of vascular headache, Vascular headaches.

Contraindication

Ergotamine (Tartrate) is contraindicated in conditions like Hypertension,Renal diseases,Hepatic disease,Chronic pulmonary disease,Vascular disease,Collagen disease,Valvular heart disease,Cachexia.

Side Effects

The severe or irreversible adverse effects of Ergotamine (Tartrate), which give rise to further complications include Ventricular fibrillation, Retroperitoneal fibrosis, Pleuropulmonary fibrosis, Endocardial fibrosis, Cerebral hemorrhage, Stroke.Ergotamine (Tartrate) produces potentially life-threatening effects which include Myocardial infarction, Renal failure, Vascular occlusions, Necrosis of bowel, Gangrene of extremities. which are responsible for the discontinuation of Ergotamine (Tartrate) therapy.The signs and symptoms that are produced after the acute overdosage of Ergotamine (Tartrate) include Nausea, Vomiting, Tachycardia, Diarrhea, Coma, Confusion, Pallor, Cold extremities.The symptomatic adverse reactions produced by Ergotamine (Tartrate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Nausea, Vomiting, Abdominal pain, Numbness, Cyanosis, Muscle pain, Oedema, Poresthesia.

Warnings

Avoid prolong administration or excessive dosage of ergotamine because of danger of gangrene, ergotism and patients become dependent upon it. It is Contraindicated in Pregnancy Risk of renal Vasoconstriction Avoid in liver impairment

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.