Doxazosin (Mesylate)
Doxazosin (Mesylate) Information

About Doxazosin (Mesylate)

Doxazosin (Mesylate) is a quinazoline derivative that blocks certain of the alpha adrenergic receptors, used as an anihypertensive agent. Doxazosin (Mesylate) is adrenergic alpha1 blocking agent. Doxazosin (Mesylate) is used to treat hypertension (high blood pressure). It lowers the blood pressure by relaxing and dilating the blood vessels. It may also be used for treating heart failure and in males for prostate enlargement symptoms such as urinary hesitancy and/or urgency.

Indications

Doxazosin (Mesylate) is primarily indicated in conditions like Benign prostatic hyperplasia, Hypertension.

Contraindication

Doxazosin (Mesylate)

Side Effects

The severe or irreversible adverse effects of Doxazosin (Mesylate), which give rise to further complications include Orthostatic hypotension.The symptomatic adverse reactions produced by Doxazosin (Mesylate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Diarrhea, Anxiety, Dyspnea, Palpitation, Insomnia, Lethargy, VertigoX, Somnolence, Edema, Sexual dysfunction, Syncope, Rhinitis, Chest pain, dizziness.

Warnings

Doxazosin should be used with caution in patients with hepatic disease (the drug is primarily metabolized by the liver) and administration of noral doses of drug may results in exaggerated effects in these patients. Patients with renal impairment should be monitored carefully for exaggerated effects, such as first-dose hypotensive reaction or prolonged hypotension. It is classified as FDA pregnancy category B. This medication should be used only when clearly needed during pregnancy or lactation. Blood pressure should be monitored for 2-6 hours following the first dose and with each subsequent increase in dose because postural hypotensive effects are most likely to occur during this time. Dosages should be adjusted as necessary depending on patient tolerance as evidenced by standing blood pressure. It should not be administered to any patient who has hypotension. Elderly patients are more likely to be susceptible to hypotensive effects.

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.