Disopyramide
Disopyramide Information

About Disopyramide

Disopyramide is a sodium channel blocking agent. Disopyramide is used as an antiarrythmic agent. Disopyramide is a class IA drug and shows similar action to that of quinidine and procainamide.

Indications

Disopyramide is primarily indicated in conditions like Arrhythmias following surgical procedures, Conversion of atrial fibrillation, Digitalis induced arrythmias, Duodenal ulceration, Hypertrophic cardiomyopathy, Premature systoles, Supraventricular tachycardia, Tobacco amblyopia and leber's optic atrophy, Ventricular tachycardia, Wolf-parkinson-white syndrome.

Contraindication

Disopyramide is contraindicated in conditions like Cardiogenic shock,Hypotension,Left ventricular failure,Digitalis toxicity,Second or third degree A-V block.

Side Effects

The severe or irreversible adverse effects of Disopyramide, which give rise to further complications include Glaucoma, Jaundice, Jaundice, Urinary retention, Myasthenia gravis, Urinary retention.Disopyramide produces potentially life-threatening effects which include Hypoglycemia, Hypoglycemia, Negative ionotropic effects, QRS widening, QT prolongation, Hypoglycemia, Torsades de pointes. which are responsible for the discontinuation of Disopyramide therapy.The signs and symptoms that are produced after the acute overdosage of Disopyramide include Bradycardia, Cardiac arrhythmias, Apnea, ECG alterations, Unconsciousness, Ventricular fibrillation.The symptomatic adverse reactions produced by Disopyramide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Fatigue, Constipation, Abdominal pain, Sweating, Dry mouth, Blurred vision, Skin rash, Weight gain, Xerostomia, Xerosis, Dry mouth.

Warnings

Reduce doses of disopyramide in case of kidney or liver impairment, carefully monitor ECG. Correct any potassium deficit before initiating therapy because disopyramide may be ineffective in hypokalemia or its toxicity is enhanced in hyperkalemia. It should be used with caution in patient with diabetes mellitus. It is classified as pregnancy category C and use of disopyramide should be avoided during pregnancy unless the potential benefit justifies the risk to the fetus.

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.