Disodium Edetate (Dihydrate)
Disodium Edetate (Dihydrate) Information

About Disodium Edetate (Dihydrate)

Disodium Edetate (Dihydrate) is used in emergency treatment of hypercalcemia and to control digitalis induced cardiac arrhythmias.

Indications

Disodium Edetate (Dihydrate) is primarily indicated in conditions like Calcified corneal opacity, Cardiac glycoside-induced arrhythmia, Hypercalcaemia.

Contraindication

Disodium Edetate (Dihydrate) is contraindicated in conditions like Renal diseases.

Side Effects

The severe or irreversible adverse effects of Disodium Edetate (Dihydrate), which give rise to further complications include Renal tubular changes, Engorgement of reticuloendothelial cells, Coarse eosinophilic granules, Hemorrhage.Disodium Edetate (Dihydrate) produces potentially life-threatening effects which include Convulsions, Arrhythmias, Cardiac Arrest, Cardiac arrest, Hypocalcemia. which are responsible for the discontinuation of Disodium Edetate (Dihydrate) therapy.The symptomatic adverse reactions produced by Disodium Edetate (Dihydrate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Fatigue, Nausea, Diarrhea, Fever, Chills, Hypotension, Dermatitis, Local burning, Abdominal cramping pain, Paresthesias, Tetany, Reaction at injection site, Respiratory arrest.

Warnings

Disodium edetate should be used with caution in patients with limited cardiac reverse or congestive heart failure. After infusion, have patients remain supine for short period of time, because there is a possibility of postural hypotension. The cardiac status of the patient should be determined before administering edetate disodium. The drugs negative inotropic effects could adversely affect a patient with cardiac disease. It should be used with caution in patients with a potassium deficiency. Edetate disodium is not recommended for use in patients with calcified tubercular lesions which that have healed or in patients with active tuberculosis.Because edetate disodium chelates and reduces serum calcium, it should not be used in patientswith hypocalcemia or in patients with normal serum calcium values. Edetate disodium is classified as pregnancy category C. It should be used with caution during pregnancy only if the potential benefit outweighs the risk to the fetus.

High Risk Groups

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.