Diphenoxylate (HCl)
Diphenoxylate (HCl) Information

About Diphenoxylate (HCl)

Diphenoxylate (HCl) is a synthetic derivative of pethidine with little or no analgesic activity. It reduces the gut motility and is used to treat diarrhea.

Indications

Diphenoxylate (HCl) is primarily indicated in conditions like Diarrhoea.

Contraindication

Diphenoxylate (HCl) is contraindicated in conditions like Ulcerative colitis,Pseudomembranous colitis,Intestinal obstruction,Colitis,Crohn's disease,Hepatic dysfunction.

Side Effects

The severe or irreversible adverse effects of Diphenoxylate (HCl), which give rise to further complications include Pancreatitis, Paralytic ileus, Hyperglycemia, Hemorrhagic colitis, Hyperglycemia, Hemorrhagic colitis, Toxic megacolon.Diphenoxylate (HCl) produces potentially life-threatening effects which include Anaphylactoid reactions, Pseudomembranous colitis, Portosystemic encephalopathy, Inflammatory bowel disease, Portosystemic encephalopathy. which are responsible for the discontinuation of Diphenoxylate (HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Diphenoxylate (HCl) include Flushing, Tachycardia, Coma, Hyperthermia, Urinary retention, Respiratory depression, Nystagmus, Lethargy, Pinpoint pupils, Dry mucous membrane, Hypotonic reflexes, Narcosis.The symptomatic adverse reactions produced by Diphenoxylate (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Abdominal distension, Dizziness, Headache, Drowsiness, Nausea, Vomiting, Anorexia, Restlessness, Confusion, Urticaria, Pruritus, Lethargy, Sedation, Hallucination, Malaise, Depression, SomnolenceX, Euphoria, Hypersensitivity reactions, Paralytic ileus, Gum swelling, Angioedema, Confusion, dizziness, Toxic megacolon.

Warnings

Patient should observe caution while driving or performing other task requiring alertness because it may cause drowsiness. Diphenoxylate should be used with caution in patients with impaired liver function. Avoid use in patients with jaundice. It should be used with caution in young children, because of greater variability of response in this age group. It is not recommended for use in infant. Patients with inflammatory bowel disease should be carefully observed if receiving diphenoxylate for sign of toxic megacolon.

High Risk Groups

Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.