Dinoprostone
Dinoprostone Information

About Dinoprostone

Dinoprostone is a prostaglandin E2 (PGE2). Dinoprostone is used as an oxytocic for induction of abortions or in miscarriages and certain conditions of the womb (uterus).

Indications

Dinoprostone is primarily indicated in conditions like Abortion, Hydatidiform mole, Labor induction, Uterine atonia.

Contraindication

Dinoprostone is contraindicated in conditions like Asthma,Glucoma,Hepatic disease,Pulmonary disease,Pelvic inflammatory disease.

Side Effects

The severe or irreversible adverse effects of Dinoprostone, which give rise to further complications include Severe pain, Acute fetal distress.Dinoprostone produces potentially life-threatening effects which include Cardiogenic collapse. which are responsible for the discontinuation of Dinoprostone therapy.The signs and symptoms that are produced after the acute overdosage of Dinoprostone include Uterine hypertonus.The symptomatic adverse reactions produced by Dinoprostone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Nausea, Vomiting, Diarrhea, Erythema, Flushing, Syncope, Vaginal burning, Pallor, Transient pyrexia.

Warnings

Dinoprostone should be used with caution in patients with medical history, including any allergy (especially drug allergy), pelvic infections, heart, lungs, kidney or liver diseases, high or low blood pressure, anemia, cervicitis, diabetes mellitus, acute vaginitis, infected endocervical lesions, compromised uterus, or a history of asthma, hypertension, hypotension, epilepsy or other seizure disorder, or jaundice. It should not be used at term if patient have a history of caesarean section or major surgery, in patient with vasa previa or who have had unexplained vaginal bleeding during their course of pregnancy. It should not be used in case of abnormal fetal position, cephalopelvic disproportion or signs of fetal distress. Maternal problems such as a history of difficult labor or traumatic delivery, grand multiparity, or any hyperactive or hypertonic uterine patterns indicate that dinoprostone should not be used.

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.