Clomipramine (HCl)
Clomipramine (HCl) Information

About Clomipramine (HCl)

Clomipramine (HCl) is a tricyclic antidepressant. Clomipramine (HCl) is used in the treatment of (OCD) obsessive compulsive disorders (mental disorder) .

Indications

Clomipramine (HCl) is primarily indicated in conditions like Blocking-replacement, Cataplexy, Chronic diarrhoea in adults, Depression, Obsessive-compulsive disorders, Phobic states, and can also be given in adjunctive therapy as an alternative drug of choice in Autism, Pain, Premenstrual syndrome, Stuttering.

Contraindication

Clomipramine (HCl) is contraindicated in conditions like Cardiac arrhythmia,Mania,Myocardial infarction,Heart block,Narrow-angle glaucoma,Hypersensitivity,Urinary retention.

Side Effects

The severe or irreversible adverse effects of Clomipramine (HCl), which give rise to further complications include Parkinsonism, Jaundice, Seizures, Extrapyramidal symptoms, Bone marrow depression, Hypertension.Clomipramine (HCl) produces potentially life-threatening effects which include Cardiac Arrest, Mania, Stroke. which are responsible for the discontinuation of Clomipramine (HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Clomipramine (HCl) include Vomiting, Tachycardia, Convulsions, Coma, Drowsiness, Ataxia, Mydriasis, Agitation, Restlessness, Impaired impulse conduction, Stupor, Hyperactive reflexes, Muscular rigidity.The symptomatic adverse reactions produced by Clomipramine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Drowsiness, Fatigue, Ataxia, Fever, Anxiety, Palpitation, Tremors, Abdominal pain, Blurred vision, Confusion, Pruritus, Erythema, Sedation, Photosensitivity, Hallucination, Weight gain, Disorientation, Reduced salivation, Micturition, Sexual dysfunction, Nightmares, Altered EEG, Numbness, Tingling, Peripheral neuropathy, Giddiness, Mydriasis, Xerostomia, Paresthesia of extremities, Delusion, Cycloplegia.

Warnings

Clomipramine should be used with caution in patients with medical history, especially of glaucoma, prostate problems, decreased urine output, thyroid disease, breathing problems, seizure, alcohol use, heart disease, mental or emotional problems, liver or kidney disease and of any drug allergy. This medication can increase sensitivity to sunlight, avoid prolonged sun exposure, wear sunscreen and protective clothing. It should be used with caution in elderly persons because they are usually more sensitive to the effects of this medication. This drug should be used during pregnancy or lactation only if clearly needed.

High Risk Groups

Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.