Cisplatin
Cisplatin Information

About Cisplatin

Cisplatin is an antineoplatsic drug. Cisplatin is inorganic metal complex with a planar configuration discovered by Rosenderg and his cholleagues. Only the cis isomer of Cisplatin is active. Cisplatin is effective in the treatment of different cancers to slow or stop the growth of abnormal or cancerous cells. Cisplatin is used in the treatment of metastatic testicular and ovarian tumours. Cisplatin is used in combination with different anticancerous drugs to obtain best therapeutic effects and to minimize side effects or toxicities.

Indications

Cisplatin is primarily indicated in conditions like Bladder carcinoma, Metastatic germ cell cancers (seminoma and teratoma), Metastatic ovarian carcinoma, Metastatic testicular cancer, Non-small cell lung carcinoma, Small cell lung cancer, Squamous cell carcinoma.

Contraindication

Cisplatin is contraindicated in conditions like Renal failure,Bone marrow depression,Peripheral neuropathy.

Side Effects

The severe or irreversible adverse effects of Cisplatin, which give rise to further complications include Neuropathy, Hypersensitivity reactions, Ototoxicity, Reduction in creatinine clearance, Elevation in serum creatinine, Vascular toxicity, Vascular toxicity.Cisplatin produces potentially life-threatening effects which include Bone marrow aplasia, Myelosuppression, Renal damage, Anaphylactic reactions, Depression. which are responsible for the discontinuation of Cisplatin therapy.The symptomatic adverse reactions produced by Cisplatin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Anorexia, Tinnitus, Azotemia.

Warnings

Cisplatin should be used with caution in patients with pre-existing blood disorders, hearing abnormalities, kidney disease or any allergies. This medication must not be used during pregnancy or lactation.

High Risk Groups

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.