Cilastatin (Na)
Cilastatin (Na) Information

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Cilastatin (Na)

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About Cilastatin (Na)

Cilastatin (Na) is an aihibitor of enzyme dehydropeptidase I, found in the brush border of the renal tubules. Cilastatin (Na) is administered concomitantly with the antibiotic Imipenem to prevent its renal metabolism to microbiologically inactive and potentially nephrotoxic products. Cilastatin has no bacterial activity itself, and does not affect the antibacterial activity of imipenem.

Indications

Cilastatin (Na) is primarily indicated in conditions like Small cell carcinoma.

Contraindication

Cilastatin (Na) is contraindicated in conditions like Hypersensitivity to any component of product.

Side Effects

The symptomatic adverse reactions produced by Cilastatin (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Fever, Rashes, Confusion, Allergic reactions, Nausea and vomiting, Hearing loss, Taste disturbanceX, Blood disorders, Tooth and tongue discoloration.

Warnings

Neurotoxicity has been observed at very high dosage or in renal failure.

High Risk Groups

Drug should not be given to patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Dosage


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