Carbimazole
Carbimazole Information

About Carbimazole

Carbimazole used in the treatment of hyperthyroidism. Carbimazole depresses the formation of thyroid hormone.

Indications

Carbimazole is primarily indicated in conditions like Blocking-replacement, Graves disease, Hyperthyroidism.

Contraindication

Carbimazole is contraindicated in conditions like Nodular goitre,Sub-acute thyroiditis,Post-partum painless thyroiditis.

Side Effects

The severe or irreversible adverse effects of Carbimazole, which give rise to further complications include Cholestatic jaundice, Hepatic necrosis, Lupus like syndrome, Nephrotic syndrome, Insulin autoimmune syndrome.Carbimazole produces potentially life-threatening effects which include Agranulocytosis, Oropharyngeal bacterial infection. which are responsible for the discontinuation of Carbimazole therapy.The symptomatic adverse reactions produced by Carbimazole are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Fever, Loss of hair, Arthralgia, Urticarial skin rash, Vasculitis.

Warnings

Excessive dose of carbimazole (antithyroid) should not be used, because it may cause hypothyroidism or goiter Treatment should be discontinued immediately if there is any clinical or laboratory evidence of neutropenia. It is not recommended to use high dose during pregnancy or lactation.

High Risk Groups

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.